ID   MED24_ANOGA             Reviewed;        1036 AA.
AC   Q7Q6D9;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 4.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 24;
DE   AltName: Full=Mediator complex subunit 24;
GN   Name=MED24; ORFNames=AGAP005906;
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7165;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST;
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA   Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA   Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA   Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA   Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA   Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA   Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA   Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA   Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA   Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA   Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA   McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA   O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA   Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA   Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA   Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA   Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA   Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA   Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA   Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 24 family.
CC       {ECO:0000305}.
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DR   EMBL; AAAB01008960; EAA11905.4; -; Genomic_DNA.
DR   RefSeq; XP_315936.4; XM_315936.4.
DR   AlphaFoldDB; Q7Q6D9; -.
DR   SMR; Q7Q6D9; -.
DR   STRING; 7165.AGAP005906-PA; -.
DR   PaxDb; Q7Q6D9; -.
DR   GeneID; 1276573; -.
DR   KEGG; aga:AgaP_AGAP005906; -.
DR   CTD; 1276573; -.
DR   VEuPathDB; VectorBase:AGAP005906; -.
DR   eggNOG; ENOG502QPJD; Eukaryota.
DR   HOGENOM; CLU_007484_0_0_1; -.
DR   InParanoid; Q7Q6D9; -.
DR   OMA; TWQDICL; -.
DR   OrthoDB; 40430at2759; -.
DR   PhylomeDB; Q7Q6D9; -.
DR   Proteomes; UP000007062; Chromosome 2L.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   InterPro; IPR021429; Mediator_Med24.
DR   PANTHER; PTHR12898; PTHR12898; 1.
DR   Pfam; PF11277; Med24_N; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleotide-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..1036
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   24"
FT                   /id="PRO_0000305918"
SQ   SEQUENCE   1036 AA;  115489 MW;  8DE325251772D736 CRC64;
     MIMDNSKTTS KTTLLKLMLL RAWKERWTDC QWGINVKTIL TRGVSGDVYN LADAIIQQAV
     VGSGANMLFL SYLKHSLCAH LISHAAVLNR IAKYDQYDKH HCLIALLDFL KSIIDGVTCR
     GKQEEAILTK ATVSLVHWLL QIYECVLQSY AEDSTLQPEE EEVVQRVAVV LERIVENPFL
     LGVLSIGKCD DPELFIALQK RFNGISNLTL TTGYVANVGA GNANSLTVTD CMRKLVLLEV
     DALEMRPFDG GKVEPITYSL QPLIAIEVLL NPMCDTHQYV AQLINLKRLK GFTYARLYCE
     LMRGCLIALN NVEGTAKESL LCAFAFIKVP HILHQLHAKT NGAEQQDEAT GATYSVEVLE
     AFELLLQDTP VLDYMDMKCA CNVVECLLKE MVKLQLLTDT HVKQLVALRE PVTAGLHKLD
     ANSAPLTMML KFVFRVESPL AGILKALSTD CSKVQDALLA MLCQVLTGNS LDLVLSVASV
     EGKFKAFISG LLKCNDYAKQ ATTAEIGKAP TTRSALFDVS FMILASIAQS YGSDVILAEG
     GNSFFEKWVR DYMVERKKTK SPMTMVKQAD PMVLEELIMA MNNSEGMYVG LKASSLRWED
     ICYTIPALVH QVLMAWESES IAPLEIKKML DGLKAYFSTF AVCAASWLCA YMQMVRQDEQ
     LKPMNMVQQL CSALAGPLAD EWQQQDYCKE RFGLMGQIVR RMQQEFLRTP QVNPKLRALF
     PSQQQQHVVS HLPLEEQFEE AWKAIAERGW LPIETTFLLD TLLQSCGPAW LVEKLIGKLF
     VCKYVRDLNK TMDIIFAIMH LDIERCTIAL LSQLVPMMLL NKAQTPDIVD PQSRVLAKLC
     VYCIIVTMET SLTATKKRTR GTASSELEDL DALCTSAKLR KIELDGMGVG CTEAATGGAS
     GTEFSLDSAL EPTASAWTTE AASIATLKEP LQSCLQTLFR TFAQHIATDE LSPKVYFVFQ
     FLSLLVESGR ERIMCVLKLL PNGLVQSLLK INATDEMTVG LILRLYDLNT PSGRQFAMSD
     ICLLRNIQMR KESIKL