ID   MED24_CHICK             Reviewed;         986 AA.
AC   Q5F3M0;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 24;
DE   AltName: Full=Mediator complex subunit 24;
GN   Name=MED24; ORFNames=RCJMB04_13m7;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 24 family.
CC       {ECO:0000305}.
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DR   EMBL; AJ851630; CAH65264.1; -; mRNA.
DR   RefSeq; NP_001026534.1; NM_001031363.1.
DR   AlphaFoldDB; Q5F3M0; -.
DR   SMR; Q5F3M0; -.
DR   STRING; 9031.ENSGALP00000021958; -.
DR   PaxDb; Q5F3M0; -.
DR   GeneID; 426134; -.
DR   KEGG; gga:426134; -.
DR   CTD; 9862; -.
DR   VEuPathDB; HostDB:geneid_426134; -.
DR   eggNOG; ENOG502QPJD; Eukaryota.
DR   InParanoid; Q5F3M0; -.
DR   OrthoDB; 739187at2759; -.
DR   PhylomeDB; Q5F3M0; -.
DR   PRO; PR:Q5F3M0; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; ISS:AgBase.
DR   GO; GO:0046966; F:nuclear thyroid hormone receptor binding; ISS:AgBase.
DR   GO; GO:0003713; F:transcription coactivator activity; ISS:AgBase.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0060261; P:positive regulation of transcription initiation from RNA polymerase II promoter; ISS:AgBase.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:AgBase.
DR   InterPro; IPR021429; Mediator_Med24.
DR   PANTHER; PTHR12898; PTHR12898; 1.
DR   Pfam; PF11277; Med24_N; 1.
PE   2: Evidence at transcript level;
KW   Activator; Nucleus; Reference proteome; Repeat; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..986
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   24"
FT                   /id="PRO_0000305914"
FT   MOTIF           128..132
FT                   /note="LXXLL motif 1"
FT   MOTIF           341..345
FT                   /note="LXXLL motif 2"
FT   MOTIF           445..449
FT                   /note="LXXLL motif 3"
FT   MOTIF           554..558
FT                   /note="LXXLL motif 4"
FT   MOTIF           785..789
FT                   /note="LXXLL motif 5"
FT   MOTIF           855..859
FT                   /note="LXXLL motif 6"
SQ   SEQUENCE   986 AA;  110844 MW;  BD1356E3B9B52504 CRC64;
     MKVVNLKQAI LQAWKERWSD YQWAINMKRF FPRGATWDIL NLAEALLEQA MIGPSPNPLI
     LSYLKYAISS QMVSYSTVLT AISKFDDFSR DLCVQSLLEI MDMFCDRLSC HGRAEECIGL
     CRALMSALNW LLRCAAFYAE KVKEMLEQVA AEGQMKMCLE RLEKMLSSTK NRALIHIAQL
     EETSSWNAVE QSLLKLEESL NGLSNSTLRS QADDCISLIK SIPTMLSVRS EQLNKTGFPT
     VHAVVLLEGT MNLTGEIQPL VEQLMMVKRM QRIPPPLFML EIWKACFVGL IESPEGTEEL
     KWTAFTFLKI PQVLVELKNY PHGDKDFTED VNCAFEFLLK LTPLLDKADQ RCNCNCMSLL
     LQECSKQGLL SEANMTNLTD KRKADREDAP QLQSAENANI QPNPRLILRA EPTVTNILKT
     MDADHSKSPE GLLGVLGHML SGKSLDLLLA AAAATGKLKS FAWKFIKLNE FTKHISTENS
     KSAPVRALLF DISFLMLCHV AQTYGSEVIL SESRPADEVP FFETWMLTCM PEEGKILNPD
     HPCFRPDSTK VESLVALLNN SSEMKLVQIN WHEVCLSISA AILEILNAWE NSVLTFESIQ
     KITDNIKGKV CSMAVCAVAW LVAHVRMLGL DEREKSLQMI RQLATPLYGD NTLQFYNERV
     VIMSSILEHM CADVLQQTAT QIKFPSTGMD TIPYWNLLPP KKPIKEVLTS VFTKVLEKGW
     VDSRSIHIFD SLLHMGGVYW FCNNLVKELL KETRKEHTLR AVELLYAIFC LDMQQLTLTL
     LGHILPNLLT DSSKWHTLMD PPGKALAKLS VWCALSSYSS HNKGQASARQ KKRHREDIED
     YISLFPLDDT RPSKLMRLLS SNEEDANILS SPNRSMSSSL SASQLHAVSM RDPLNRVLAN
     LFLLISSILG SKTAGTHTQF VQWFMEECVD CLEQGSHGSI LQFMPFTMVS ELVKVSTMSS
     PKIVLAITDL GLPLGRRVAA KAIAAL