MED24_DICDI
ID MED24_DICDI Reviewed; 2036 AA.
AC Q54GV0;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 13-OCT-2009, sequence version 2.
DT 25-MAY-2022, entry version 71.
DE RecName: Full=Putative mediator of RNA polymerase II transcription subunit 24;
DE AltName: Full=Putative mediator complex subunit 24;
DE AltName: Full=Putative mediator complex subunit 5;
DE AltName: Full=Putative mediator of RNA polymerase II transcription subunit 5;
GN Name=med24; Synonyms=med5; ORFNames=DDB_G0289971;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP NOMENCLATURE.
RX PubMed=18515835; DOI=10.1093/nar/gkn349;
RA Bourbon H.-M.;
RT "Comparative genomics supports a deep evolutionary origin for the large,
RT four-module transcriptional mediator complex.";
RL Nucleic Acids Res. 36:3993-4008(2008).
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 24 family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000149; EAL62498.2; -; Genomic_DNA.
DR RefSeq; XP_635969.2; XM_630877.2.
DR AlphaFoldDB; Q54GV0; -.
DR STRING; 44689.DDB0266954; -.
DR PaxDb; Q54GV0; -.
DR EnsemblProtists; EAL62498; EAL62498; DDB_G0289971.
DR GeneID; 8627384; -.
DR KEGG; ddi:DDB_G0289971; -.
DR dictyBase; DDB_G0289971; med24.
DR eggNOG; ENOG502RDM1; Eukaryota.
DR HOGENOM; CLU_233347_0_0_1; -.
DR InParanoid; Q54GV0; -.
DR OMA; YFYFTIP; -.
DR PRO; PR:Q54GV0; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0016592; C:mediator complex; ISS:dictyBase.
DR GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR InterPro; IPR021429; Mediator_Med24.
DR PANTHER; PTHR12898; PTHR12898; 3.
PE 3: Inferred from homology;
KW Activator; Coiled coil; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..2036
FT /note="Putative mediator of RNA polymerase II transcription
FT subunit 24"
FT /id="PRO_0000388645"
FT REGION 51..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 159..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 212..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 501..580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 754..840
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 928..1124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1375..1419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1565..1608
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 505..584
FT /evidence="ECO:0000255"
FT COILED 943..977
FT /evidence="ECO:0000255"
FT COILED 1915..1968
FT /evidence="ECO:0000255"
FT COMPBIAS 212..227
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 252..270
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..380
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..451
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 754..825
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 928..946
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 960..1124
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2036 AA; 231208 MW; 6AD0AA364282692D CRC64;
MISMMETSTT EKKSNTDNSI LKKIIIDSWR QRLSPIEWSL KLYNGFYNNN NNNNSNNNNN
NNNNNNNNNV DNNEINSIEL CEILLDLMNI GQSPSPLLVS YLRYAISIKL IGYNEFFESV
YKFSSISRAQ HFSVILDILF DVINIINYPS HHQNIFNSDN IENSNNNNNN NNNNNNNNSN
NNIGFKVSSL SSSLKRNNSK IISTPIVTLL SSPSPSSSSS SSTSPSSQQP QPPQPQPLSY
TSPIKKTVLI KNPDSTDSDE IMKVKEEPIK FKTTTTTTST TTTTSTTSTT TNEISSSPPT
NGNGEETTIT TKTEDSNGIN GIDSEDHKGE NGKASPQMNG VHPGSDGNIS HKRKEMDSNT
IFDDDDSNGV DQHCSNKKMK HTDTLTQPQP KQIQNPQQQE QQQQQQENIE QNQHGNLHLH
QPSQQQQQQQ QQTSQPSLTT TTASAVTQTT TTASTINKST KATTKKNYHK QLLSFTRLAT
LLFKVIEYYF QEDERINNIN KSVNNNNNNN NNNNNNNNNN NNNNYNNNNN DSMDQNSNNP
AVKYNSNNNN INNNNNNNNN NNNNNNNNNN NNNNNNNNNN INNILYKNSV KSLEILSIIQ
NNSTFKTLIY LAKYEFTLSS FKDLVLPFLA IQNSIRDNIV KQNIPSTQLI SSQVKGQEFA
SQQTQLLNPL FQLIKQKYQK LFIDFRRILI NKQEILPNHD IGSLVHGSSQ SDKQIILSFE
IIIDQEINGN HFKSSHTKLA ISRGKPNELD TILNLKNNKN NNNNNNNSNG NGNGIDIGSS
TDGSNKLSST NIEEGNNNNN SSTHLNGNDQ SQQSLDDEEP KQSQQQQLPP PSPPQQSHQK
IQIQKQLQLI RQAKNLENVS DCFFKLLTLK TVKGLSDVEF LLEIVKILFQ KLVRCNPNSN
EYKKTRLFLL FKIPHFYSLM IDNYGNNNNN NNTNTNNINN NKNKNSKKSN NKNKNNKNNN
KKNKNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNG ESSDKNEINP EGSIGSNNNN
DNDNNDETNT NTSSNNNNNN NNSNDNENVT DNNKNNNSNT KNNNNSNNNN NNNNNNNNNN
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNKK NKDLNLHGNI IENVLYQINQ
FPSLYNVEDN IILSLIQILI KKHLVDINLL KSLFPNYHTD IDSIDSEIQS PPSSELSFDN
LFDIHSIADI VKIKELIESL LNNSDPNNVS IMKRLFDFIK NHLINSFDYQ DKLLNVLFNA
KNIDYDSNKL LIAVIMYIFS DPLVIDTIDV HGYTLRLVMI LIDVCESYGS STTATTTEDI
DIFKNENDNH DQKHLYFYFT IPFNLLYTLL IILYDVKNNK YNLDLIKSKL SESLNNKNNS
RKSKSNNSSN NSINNINNNN NNNNNNNNNN NNNNNNNNNN NNFIQWIYNM IKDTNFSNGN
GVNNVSTSFE FQFLKNLFDS DLGEDSIEKF QNFSQREYSS WDIVSKLPNV LYNIFDCYDR
NIIQEEKVTQ TMQLLFQYIP FSPIIVFDYL SKTKSSFFNV SPSSSTTTTT TTTSTTTTIT
TTTTNSSAYS TTTTTSASTS LPKSTDGKLL NGKSSNTSTT TTKNNGDTPT ITTVITTMSS
KNDKPLSLVE ACLTNLNENR LLFRLSDYYK SLISEDHLND LYKLFDPISE TINLLLLSPK
LQKFNELGYY SNQSTLFNSI CLTNLSPPNQ LSNMTPANAI RQVIDQFLTK SVSPNLSNLE
RDIKYIHMRL SNDLCQIVNL VSLEILDIIL QSCQIESLYS IRAMELGGYI LGGLIGIESL
PILLNSIIPS WSEHIQTSLH GQLLSYFCFS SIVNSNALYY IQTDLCIQQS FKKFFLLLND
TMKRILSVAP LNGLITFCLS TITLFIHLNH SSITTYLYNS SSNTQLINQL YEIISKNQSL
KKKQKLKQKK QQHNNNNGGE YNIDQDHIEQ IQQQQQQYQK QQQQRKDEPN YEKLEEFIKT
QYQRNNHSKL KSIFNILSIS QLEDLSMSIL NLSNFFLAIS IFEDKNDLQY CSKLFN
