ID   MED24_XENLA             Reviewed;         988 AA.
AC   Q6PI53;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 24;
DE   AltName: Full=Mediator complex subunit 24;
GN   Name=med24;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 24 family.
CC       {ECO:0000305}.
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DR   EMBL; BC043802; AAH43802.1; -; mRNA.
DR   RefSeq; NP_001080393.1; NM_001086924.1.
DR   RefSeq; XP_018089579.1; XM_018234090.1.
DR   RefSeq; XP_018089580.1; XM_018234091.1.
DR   AlphaFoldDB; Q6PI53; -.
DR   SMR; Q6PI53; -.
DR   IntAct; Q6PI53; 1.
DR   MINT; Q6PI53; -.
DR   MaxQB; Q6PI53; -.
DR   GeneID; 380085; -.
DR   KEGG; xla:380085; -.
DR   CTD; 380085; -.
DR   Xenbase; XB-GENE-968191; med24.L.
DR   OMA; TWQDICL; -.
DR   OrthoDB; 739187at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 380085; Expressed in ovary and 19 other tissues.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   InterPro; IPR021429; Mediator_Med24.
DR   PANTHER; PTHR12898; PTHR12898; 1.
DR   Pfam; PF11277; Med24_N; 1.
PE   2: Evidence at transcript level;
KW   Activator; Nucleus; Reference proteome; Repeat; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..988
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   24"
FT                   /id="PRO_0000305916"
FT   MOTIF           128..132
FT                   /note="LXXLL motif 1"
FT   MOTIF           341..345
FT                   /note="LXXLL motif 2"
FT   MOTIF           445..449
FT                   /note="LXXLL motif 3"
FT   MOTIF           555..559
FT                   /note="LXXLL motif 4"
FT   MOTIF           786..790
FT                   /note="LXXLL motif 5"
FT   MOTIF           856..860
FT                   /note="LXXLL motif 6"
SQ   SEQUENCE   988 AA;  110514 MW;  B780452FE568D3C6 CRC64;
     MKLVNLKQAI LQAWKERWSD YQWAINMKKF FPKGVTWDIL NLAEALLDQA MIGPAPNPLI
     LSYLKYAINS QMVSYSTVLT AISKFDDFSR DLCIQSLLEI MDMFCDNLSC HGKAEECIGL
     CRALMSALNW LLRCATFYTD KLKDVLDPVA GENHLSMCLQ RLKSILGSTK NRALIHIAKL
     EEPTSWTSVE QSQLRLSESI SLLPSVQLRN QAEECVSLIR SIPSMLSVHS DQLQTNGFPT
     VHAVVMLEGT MNLTGDAQPL VEQMNTVKRM QRIPLHLFLL EVWKACIVGL IESPEGTEEL
     KWTAFTFLKI PQALAKLKKL SSMEQDFNED MKCAFEYLLK LTPLLDKADQ RCNCDCVSLL
     LQECNKLGLL SEQNMENLMA KRTADREQAP RLKSSENSTI QPNPGLILRA EPTVTNILKT
     MDADHSKSPE GLLGVLGHML SGKSLDLLLA AAAATGKLKS FARKFIQLNE FTRHIGVESS
     KAANVRALLF DISFLMLCHV AQTYGSEMIL SEGCPGGEMP FFESWMQTCM PGEGRVLNPD
     HPCFRHPDIA KVEALVALLN TSTEMKLAQT KWHEVCLSIP AAILEIHNAW ENGVLSSEAI
     QKITDNIKGK VCSLAVCAVA WLVAHVRMLG LDERDKSLQM IRQLGSPMFG DNTLQFYSER
     VIIMSSILDN MCSEVLQQTT TQIKFSAAGS EPMPYIHRLP PKTPIKEVLR GAFSSTLEKG
     WVDSRTLHNF DTLLHMGGVY WFCNNLVKEL LRETRLEFAL RAVELLYAIF CLDMQQLTLT
     LLGHVLPSLL TDSAKWHMLM DPPGRALAKL SVWCAMTSYS TQNKGQPSPR QRKRHREDIE
     DYSSLFPLDD TQQSKLMRLL SSNEEEHNVQ ANPVDRPMNS SLSASQIHNI SSKEPLNRVL
     ANLFLLISSV LGAKTAGAQT QFVQWFMEEC VESLELGGKG CILQFMPFSM VSELVKVSTL
     SSPKIVLAIT DLTLPLGRRV AAKALTAL