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MED26_BOVIN
ID   MED26_BOVIN             Reviewed;         599 AA.
AC   A5PK23;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 26;
DE   AltName: Full=Cofactor required for Sp1 transcriptional activation subunit 7;
DE            Short=CRSP complex subunit 7;
DE   AltName: Full=Mediator complex subunit 26;
GN   Name=MED26; Synonyms=CRSP7;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional pre-initiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex, which is composed of MED1,
CC       MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L,
CC       MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23,
CC       MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and
CC       CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
CC       module termed the CDK8 module. Mediator containing the CDK8 module is
CC       less active than Mediator lacking this module in supporting
CC       transcriptional activation. Individual preparations of the Mediator
CC       complex lacking one or more distinct subunits have been variously
CC       termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with CEBPB (when
CC       not methylated) (By similarity). {ECO:0000250|UniProtKB:O95402,
CC       ECO:0000250|UniProtKB:Q7TN02}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 26 family.
CC       {ECO:0000305}.
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DR   EMBL; BC142325; AAI42326.1; -; mRNA.
DR   RefSeq; NP_001092358.1; NM_001098888.1.
DR   AlphaFoldDB; A5PK23; -.
DR   SMR; A5PK23; -.
DR   STRING; 9913.ENSBTAP00000006986; -.
DR   PaxDb; A5PK23; -.
DR   PRIDE; A5PK23; -.
DR   GeneID; 506331; -.
DR   KEGG; bta:506331; -.
DR   CTD; 9441; -.
DR   eggNOG; KOG1105; Eukaryota.
DR   HOGENOM; CLU_478915_0_0_1; -.
DR   InParanoid; A5PK23; -.
DR   OrthoDB; 459216at2759; -.
DR   TreeFam; TF328436; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR   GO; GO:0016592; C:mediator complex; ISS:UniProtKB.
DR   GO; GO:0003712; F:transcription coregulator activity; ISS:UniProtKB.
DR   GO; GO:0010628; P:positive regulation of gene expression; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   Gene3D; 1.20.930.10; -; 1.
DR   InterPro; IPR042376; MED26.
DR   InterPro; IPR031416; Med26_C.
DR   InterPro; IPR031417; Med26_Mid.
DR   InterPro; IPR003617; TFIIS/CRSP70_N_sub.
DR   InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR   InterPro; IPR017923; TFIIS_N.
DR   PANTHER; PTHR15201; PTHR15201; 1.
DR   Pfam; PF08711; Med26; 1.
DR   Pfam; PF15693; Med26_C; 1.
DR   Pfam; PF15694; Med26_M; 1.
DR   SMART; SM00509; TFS2N; 1.
DR   SUPFAM; SSF47676; SSF47676; 1.
DR   PROSITE; PS51319; TFIIS_N; 1.
PE   2: Evidence at transcript level;
KW   Activator; Nucleus; Phosphoprotein; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..599
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   26"
FT                   /id="PRO_0000304958"
FT   DOMAIN          10..87
FT                   /note="TFIIS N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00649"
FT   REGION          98..331
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          352..403
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          427..470
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        125..157
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        170..195
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        204..222
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        289..316
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        387..402
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        445..462
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         447
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O95402"
FT   MOD_RES         469
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O95402"
SQ   SEQUENCE   599 AA;  65515 MW;  38592548FB7DEDD9 CRC64;
     MTAAPPSPQQ IRDRLLQAID PQSNIRNMVA VQEVISSLEK YPITKEALEE TRLGKLINDV
     RKKTKNEELA KRAKKLLRSW QKLIEPVHQN EAALRGLAGA PGSANGGAHN CRPEAGAAGP
     PKSVHDLKYR NDMPRLCGQR LDRLGSRKRR GDQRDLGHPG PPPKVSKASH DSLVPNSSPL
     PTNGISGSPE SFPSPLDSSG HVGPEGNRLE HGENDKHSGK IPVNAVRPHT SSPGLGKPPG
     PCLQTKAVVL QQLDKVDETP GPPHPKGPPR CSLGSRNSRH EGSFARQRSP YTYKGSLPSP
     SPRPQSLDAT QVPSPLPLAQ PSTPPVRRLE LLPSAESPVR WLEQPEGHQR LAGLGCKAGL
     PPAEPLLPRA GFSPDSSKAD SDAASSGGSD SKKKKRYRPR DYTVNLDGQV AEAGVKPVRL
     KERKLTFDPM TRQIKPLTQK EPVRADSPVH TEQPRTELDK PEAKASLQSP FEQTNWKELS
     RNEIIQSYLS RQSSLLSSSG AQTPGAHHFM SEYLKQEEST RRGARKPHVL VPHGPPTDFP
     GLSREVTRDD LDKIQAHQWP GVNGCQDTQG NWYDWTQCIS LDPHGDDGRL NILPYVCLD
 
 
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