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MED26_DICDI
ID   MED26_DICDI             Reviewed;        2073 AA.
AC   Q552X2; Q869L1;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   13-OCT-2009, sequence version 2.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Putative mediator of RNA polymerase II transcription subunit 26;
DE   AltName: Full=Putative mediator complex subunit 26;
GN   Name=med26; ORFNames=DDB_G0275733;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 26 family.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000013; EAL69617.2; -; Genomic_DNA.
DR   RefSeq; XP_643556.2; XM_638464.2.
DR   AlphaFoldDB; Q552X2; -.
DR   STRING; 44689.DDB0266833; -.
DR   PaxDb; Q552X2; -.
DR   EnsemblProtists; EAL69617; EAL69617; DDB_G0275733.
DR   GeneID; 8620139; -.
DR   KEGG; ddi:DDB_G0275733; -.
DR   dictyBase; DDB_G0275733; med26.
DR   eggNOG; ENOG502RSRG; Eukaryota.
DR   HOGENOM; CLU_232796_0_0_1; -.
DR   InParanoid; Q552X2; -.
DR   OMA; VEMIANI; -.
DR   PRO; PR:Q552X2; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR   GO; GO:0016592; C:mediator complex; ISS:dictyBase.
DR   GO; GO:0016604; C:nuclear body; IBA:GO_Central.
DR   GO; GO:0072357; C:PTW/PP1 phosphatase complex; IBA:GO_Central.
DR   GO; GO:0008157; F:protein phosphatase 1 binding; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; ISS:dictyBase.
DR   GO; GO:1904290; P:negative regulation of mitotic DNA damage checkpoint; IBA:GO_Central.
DR   GO; GO:0032206; P:positive regulation of telomere maintenance; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISS:dictyBase.
DR   InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR   InterPro; IPR017923; TFIIS_N.
DR   Pfam; PF08711; Med26; 1.
DR   SUPFAM; SSF47676; SSF47676; 1.
PE   3: Inferred from homology;
KW   Activator; Coiled coil; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..2073
FT                   /note="Putative mediator of RNA polymerase II transcription
FT                   subunit 26"
FT                   /id="PRO_0000388661"
FT   REGION          22..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          115..146
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          241..260
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          287..334
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          796..879
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          908..1175
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1215..1260
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1403..1475
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1489..1539
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1551..1571
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1587..1645
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1804..1836
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1868..1935
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2019..2073
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          166..453
FT                   /evidence="ECO:0000255"
FT   COILED          674..710
FT                   /evidence="ECO:0000255"
FT   COILED          1884..1930
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        35..94
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        908..941
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        966..987
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1010..1175
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1403..1424
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1439..1472
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1592..1618
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1621..1645
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2073 AA;  235786 MW;  87DE9161F1C51E05 CRC64;
     MIIKKKKDWR TQLFNRSQKK TIERMRKERN NQSVEMDSHT FNNNNNNNNN NNINNNNNIN
     NNNNNNNNNN NNNNSINNYG HQHLNSSSSS QSFQDQLVQD LQSILMAQQH NIISPQLQQQ
     QQQQQQQQPS FNSNNNNNNN TNTYNFQPEA IENNNIGINS NGYNPIQQQF QQQHQLQQQI
     QQQQIQFQNQ NQNQQTHQNR QLQQQQQHQI QQLQLQQQLQ QQLQQQQQHQ QQLQQQMQHQ
     QMQQQQIPHH QQNQQLQQQQ QQQVPHQQQN QLIQQQQQQQ QQQQQQQQHQ QHQQHQQHQQ
     QHQQHQQQHQ QHQQQHQHQH QQQHQQQQQP QNQQQQQPQN QQMQQQQQQN QQMQQQQQQN
     QQMQQQMQQQ QQLQQQQQIL QQQQQIQQQQ QQQQQILQPQ QQPQQQQQQQ QLLQQQQQQQ
     LMQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQPQQQQQI QQQQPQQQPQ QQQQPQQQQS
     QQQPQPQQQQ QQQQQQQQQQ QQIQQQYVDD NGDNTLLIFI SNMCRNVEIP AFSVQPDQYY
     QYFVEKIVVI WSDLISSSGS TKMTHEETQQ QKSSLFEQCR RIIVTYPHFF NQIITERFIF
     DLEDLNSKIS DIFKQFNNNN NNNNNNAIEN SPIMAEQYKR FQTDYIIKFD QLQCFKFPDY
     SLSSIISTLN PSPLRQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQIQIQNQTI PIPPSPQPTQ
     QYQPITQLDQ QPQPQPQPQL QQQLQQTILD NNNNNNTNNT NNTNTINNNL DISNDIINSS
     NNIGLCSSPI SLENEKGNNN NNNNKINNNN NTSSSSSITI PINNTTSSPI NKNINDDINN
     NNNNNNSNNN NNNNNNNNNN NNNNNTNTNN EIKKTNNDIS TNLSMPTVVD LNSSNNITSS
     TFLLNPNINN NNNNNSSGGG GSSSSSNSNS SSPNIPNKPK KPVKSNSKKV IDLLEDNDSD
     SSDSSDSSDS SDSSDSSDSS DSDSSDSSDS SDSSDDEKKK KPKKPIVNKK NLVKTNTSTN
     SKDSKPASTA TSTTTTTTNS KPSITQPTSK IKPSSTIPSQ PTSITTKKKP ENSTTSLPAS
     TSSSSPSNTV IKSSPPISKT LPTPTSTTSL SSSSSATVNK PIPPTTKKPI STINNNTLNN
     NTNSSINKIA SNSTSTLGNK NLGTPSNYNN NNNNIGAEKK KEKALTLTES QLTNEKELPS
     LTDYIAQLNK IKKSNTTSGV TNSNNNNNNN NNNNNNNNNN NNNNNNNNKG TTTSTTTVIN
     DPNKKKISWK DEKGGCSVVD RVPMFIQEFS ECVTWPRIRE FLIVIDSKMS NACKKRFLEL
     GGLANIHTVL KYSQETVTIP RDTIIALKGL KGLPVTVEHL HAEKLIGKTI RSFKKHSNPN
     VKEYAEELES EWMYLIKGGA TSNTSSTTSS ASSSSSSSIS NGNNSDKKRN RDQPITDTSK
     KLKSSSSSSS SSSSSSSSTN ARSSSPVPNT QLPPKKSIIK EYDDLFMNKL STPSSSSSSS
     SSSSSSSTTT TTTSTGSTIP LSPPPSSSSS SNNNNSLSPI MTFKTKQSIA AAAAKKQQTQ
     ELSDSTAKSL SSNGATTKLF AAMVDKKSQT KPGGGSGGSS NVSGKSDSSQ TLLESIGISW
     DTPTKEEEDL TPVPDPNRRK SSKGKVSVKW LSDEKLVNVK EFCKEEIADA KANEEYELEQ
     SKRFELETER LLGFKPMKAT LEWKKPIPIE DTQLPDIKLY GSESLEKDIQ FERENFTLME
     FYIGSNIPDT PKEPDDEQKD YDDKDVLIIP SGDINDVFDD SKINELMNVI PPILSDQIND
     DNIINNNNNT HSNSPDENNT KMINDENNDP NNTGSSNKVV EMIANIDPNN NNNNNNINNN
     NNIINNINNN NNNNMNNNNM GNMNNMGNMN NQFNNMNNNN NNNQFNNGYN NNNNNNNNNN
     NNNNNNNNNM MGYNNGYNMN NGNQFNNNYN GVYQNNGFNN FNNQYNNGQY NGYNNSNGQF
     NNNNNNVYNN NNNNQFNNNF NQYNNNNNNN FNQNFNNGFN NNNNNNNQYN NGYNNFNNNN
     NYGNMNNYNN NNNNYYNNNN NNNNNNNNNQ SYS
 
 
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