MED26_DICDI
ID MED26_DICDI Reviewed; 2073 AA.
AC Q552X2; Q869L1;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 13-OCT-2009, sequence version 2.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Putative mediator of RNA polymerase II transcription subunit 26;
DE AltName: Full=Putative mediator complex subunit 26;
GN Name=med26; ORFNames=DDB_G0275733;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 26 family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000013; EAL69617.2; -; Genomic_DNA.
DR RefSeq; XP_643556.2; XM_638464.2.
DR AlphaFoldDB; Q552X2; -.
DR STRING; 44689.DDB0266833; -.
DR PaxDb; Q552X2; -.
DR EnsemblProtists; EAL69617; EAL69617; DDB_G0275733.
DR GeneID; 8620139; -.
DR KEGG; ddi:DDB_G0275733; -.
DR dictyBase; DDB_G0275733; med26.
DR eggNOG; ENOG502RSRG; Eukaryota.
DR HOGENOM; CLU_232796_0_0_1; -.
DR InParanoid; Q552X2; -.
DR OMA; VEMIANI; -.
DR PRO; PR:Q552X2; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0016592; C:mediator complex; ISS:dictyBase.
DR GO; GO:0016604; C:nuclear body; IBA:GO_Central.
DR GO; GO:0072357; C:PTW/PP1 phosphatase complex; IBA:GO_Central.
DR GO; GO:0008157; F:protein phosphatase 1 binding; IBA:GO_Central.
DR GO; GO:0003712; F:transcription coregulator activity; ISS:dictyBase.
DR GO; GO:1904290; P:negative regulation of mitotic DNA damage checkpoint; IBA:GO_Central.
DR GO; GO:0032206; P:positive regulation of telomere maintenance; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISS:dictyBase.
DR InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR InterPro; IPR017923; TFIIS_N.
DR Pfam; PF08711; Med26; 1.
DR SUPFAM; SSF47676; SSF47676; 1.
PE 3: Inferred from homology;
KW Activator; Coiled coil; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..2073
FT /note="Putative mediator of RNA polymerase II transcription
FT subunit 26"
FT /id="PRO_0000388661"
FT REGION 22..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 115..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 241..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 287..334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 796..879
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 908..1175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1215..1260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1403..1475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1489..1539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1551..1571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1587..1645
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1804..1836
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1868..1935
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2019..2073
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 166..453
FT /evidence="ECO:0000255"
FT COILED 674..710
FT /evidence="ECO:0000255"
FT COILED 1884..1930
FT /evidence="ECO:0000255"
FT COMPBIAS 35..94
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 908..941
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 966..987
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1010..1175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1403..1424
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1439..1472
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1592..1618
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1621..1645
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2073 AA; 235786 MW; 87DE9161F1C51E05 CRC64;
MIIKKKKDWR TQLFNRSQKK TIERMRKERN NQSVEMDSHT FNNNNNNNNN NNINNNNNIN
NNNNNNNNNN NNNNSINNYG HQHLNSSSSS QSFQDQLVQD LQSILMAQQH NIISPQLQQQ
QQQQQQQQPS FNSNNNNNNN TNTYNFQPEA IENNNIGINS NGYNPIQQQF QQQHQLQQQI
QQQQIQFQNQ NQNQQTHQNR QLQQQQQHQI QQLQLQQQLQ QQLQQQQQHQ QQLQQQMQHQ
QMQQQQIPHH QQNQQLQQQQ QQQVPHQQQN QLIQQQQQQQ QQQQQQQQHQ QHQQHQQHQQ
QHQQHQQQHQ QHQQQHQHQH QQQHQQQQQP QNQQQQQPQN QQMQQQQQQN QQMQQQQQQN
QQMQQQMQQQ QQLQQQQQIL QQQQQIQQQQ QQQQQILQPQ QQPQQQQQQQ QLLQQQQQQQ
LMQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQPQQQQQI QQQQPQQQPQ QQQQPQQQQS
QQQPQPQQQQ QQQQQQQQQQ QQIQQQYVDD NGDNTLLIFI SNMCRNVEIP AFSVQPDQYY
QYFVEKIVVI WSDLISSSGS TKMTHEETQQ QKSSLFEQCR RIIVTYPHFF NQIITERFIF
DLEDLNSKIS DIFKQFNNNN NNNNNNAIEN SPIMAEQYKR FQTDYIIKFD QLQCFKFPDY
SLSSIISTLN PSPLRQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQIQIQNQTI PIPPSPQPTQ
QYQPITQLDQ QPQPQPQPQL QQQLQQTILD NNNNNNTNNT NNTNTINNNL DISNDIINSS
NNIGLCSSPI SLENEKGNNN NNNNKINNNN NTSSSSSITI PINNTTSSPI NKNINDDINN
NNNNNNSNNN NNNNNNNNNN NNNNNTNTNN EIKKTNNDIS TNLSMPTVVD LNSSNNITSS
TFLLNPNINN NNNNNSSGGG GSSSSSNSNS SSPNIPNKPK KPVKSNSKKV IDLLEDNDSD
SSDSSDSSDS SDSSDSSDSS DSDSSDSSDS SDSSDDEKKK KPKKPIVNKK NLVKTNTSTN
SKDSKPASTA TSTTTTTTNS KPSITQPTSK IKPSSTIPSQ PTSITTKKKP ENSTTSLPAS
TSSSSPSNTV IKSSPPISKT LPTPTSTTSL SSSSSATVNK PIPPTTKKPI STINNNTLNN
NTNSSINKIA SNSTSTLGNK NLGTPSNYNN NNNNIGAEKK KEKALTLTES QLTNEKELPS
LTDYIAQLNK IKKSNTTSGV TNSNNNNNNN NNNNNNNNNN NNNNNNNNKG TTTSTTTVIN
DPNKKKISWK DEKGGCSVVD RVPMFIQEFS ECVTWPRIRE FLIVIDSKMS NACKKRFLEL
GGLANIHTVL KYSQETVTIP RDTIIALKGL KGLPVTVEHL HAEKLIGKTI RSFKKHSNPN
VKEYAEELES EWMYLIKGGA TSNTSSTTSS ASSSSSSSIS NGNNSDKKRN RDQPITDTSK
KLKSSSSSSS SSSSSSSSTN ARSSSPVPNT QLPPKKSIIK EYDDLFMNKL STPSSSSSSS
SSSSSSSTTT TTTSTGSTIP LSPPPSSSSS SNNNNSLSPI MTFKTKQSIA AAAAKKQQTQ
ELSDSTAKSL SSNGATTKLF AAMVDKKSQT KPGGGSGGSS NVSGKSDSSQ TLLESIGISW
DTPTKEEEDL TPVPDPNRRK SSKGKVSVKW LSDEKLVNVK EFCKEEIADA KANEEYELEQ
SKRFELETER LLGFKPMKAT LEWKKPIPIE DTQLPDIKLY GSESLEKDIQ FERENFTLME
FYIGSNIPDT PKEPDDEQKD YDDKDVLIIP SGDINDVFDD SKINELMNVI PPILSDQIND
DNIINNNNNT HSNSPDENNT KMINDENNDP NNTGSSNKVV EMIANIDPNN NNNNNNINNN
NNIINNINNN NNNNMNNNNM GNMNNMGNMN NQFNNMNNNN NNNQFNNGYN NNNNNNNNNN
NNNNNNNNNM MGYNNGYNMN NGNQFNNNYN GVYQNNGFNN FNNQYNNGQY NGYNNSNGQF
NNNNNNVYNN NNNNQFNNNF NQYNNNNNNN FNQNFNNGFN NNNNNNNQYN NGYNNFNNNN
NYGNMNNYNN NNNNYYNNNN NNNNNNNNNQ SYS