MED26_DROPS
ID MED26_DROPS Reviewed; 1602 AA.
AC Q29CV2;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-JAN-2009, sequence version 2.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 26;
DE AltName: Full=Mediator complex subunit 26;
GN Name=MED26; ORFNames=GA14731;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 26 family.
CC {ECO:0000305}.
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DR EMBL; CH475401; EAL29261.2; -; Genomic_DNA.
DR RefSeq; XP_001352375.2; XM_001352339.3.
DR AlphaFoldDB; Q29CV2; -.
DR SMR; Q29CV2; -.
DR STRING; 7237.FBpp0272392; -.
DR PRIDE; Q29CV2; -.
DR EnsemblMetazoa; FBtr0273954; FBpp0272392; FBgn0074758.
DR GeneID; 4811809; -.
DR KEGG; dpo:Dpse_GA14731; -.
DR eggNOG; ENOG502S9CY; Eukaryota.
DR HOGENOM; CLU_249548_0_0_1; -.
DR InParanoid; Q29CV2; -.
DR OMA; NCDDVNN; -.
DR ChiTaRS; MED26; fly.
DR Proteomes; UP000001819; Chromosome 5.
DR Bgee; FBgn0074758; Expressed in insect adult head and 2 other tissues.
DR GO; GO:0016592; C:mediator complex; ISS:UniProtKB.
DR GO; GO:0003712; F:transcription coregulator activity; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR Gene3D; 1.20.930.10; -; 1.
DR InterPro; IPR042376; MED26.
DR InterPro; IPR003617; TFIIS/CRSP70_N_sub.
DR InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR InterPro; IPR017923; TFIIS_N.
DR PANTHER; PTHR15201; PTHR15201; 1.
DR Pfam; PF08711; Med26; 1.
DR SMART; SM00509; TFS2N; 1.
DR SUPFAM; SSF47676; SSF47676; 1.
DR PROSITE; PS51319; TFIIS_N; 1.
PE 3: Inferred from homology;
KW Activator; Coiled coil; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..1602
FT /note="Mediator of RNA polymerase II transcription subunit
FT 26"
FT /id="PRO_0000304963"
FT DOMAIN 8..85
FT /note="TFIIS N-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00649"
FT REGION 86..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 238..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 399..481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 580..617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 694..736
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1035..1158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1372..1407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 792..820
FT /evidence="ECO:0000255"
FT COMPBIAS 86..106
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..260
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 400..415
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 416..430
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 431..465
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 587..617
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 706..731
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1035..1049
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1050..1075
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1076..1103
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1125..1147
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1602 AA; 178182 MW; ADD5BBC9394DC725 CRC64;
MNQNQIQQLT SHLSQALDQN YDVVNMDAVL SVICALEGTT ITKEQLEATR LAKYINQLRR
RTKNEHLARR AKSLLKMWRE MVGIQQTAND SQHHHSQPTS LPTPPSAHFY KYTAGSADSN
LTETVVHLPV SPSVPSHRTI SDLHSNIDSS EPPPAVLPSQ HQSNFLNLIN NISKCEREES
NSSMLIQAHK QPQSQQFQNR PLGLPLPFIS EQSLNSVSIS SDVGNDKKGE ASIVIDIVTD
SDENDNESAS TIQGKPTAAA SAPFTISPAP CPRPKKFKKD KKHKERDRSK SSLLAQNELI
GQHSSRYSAK VKEGQSQTAQ ATDSEIFSLS NSSMSSILSG DAALLNPQHK FRANASELTF
TGRFKPVNHL DSANQDNSAL PIGQNIVFRQ NESERPIFED SITNDSSTSC SRLSPPTVEE
RRKSDKIDDS IRQQIATSIQ MPMPSIGLGH ESNSRTEYLE NSSKSQVPKK RGRKKGSKGV
DAVIAKESSS LSQQIFFGVG STVKKVKTTK ELFSEIQSRK LITAVQSPTS NISNSSISRE
LTTRALMPRP TSSCSDTSIH SPQIMETYSG NVTLMGVDKF SNKNEDAGNT DSDTITSEPS
QDSNKSQEIK ECTSLDSNSN SLQTLSLAKK SMHTSKSENY SDVTTQLMHL IHSIKGPLSV
YEVEKLYRAQ IVPCTCLVIE EICNPFGEPI NLSSDNGVGD PKSDSNNDNV SRHKKQEEQL
PKLERLSDND FSMDTPQKPV KSIFDLDFDE DEDPLQSIIN DIRMPPTKLE ETKENADLKN
ALAHLPMNIS SLDVASVNAD TVQNQINSHN QEGETSEEQN VAIPVFTCHE DPDCVAKQRF
HVQTNKVNNF HINALHNFYI PNINGNWDSI DSSIVSESTI TDFLNTLGSY TVTDGADVVP
KYGSLTYDRI RKDLSSIKFT SSFKTRPLKS FMPPFLGVAK CLPTCRLARS SFKKKQIQSP
PPPLIVIPST IEGLDPDIMQ KDYNGGSPLK VDVDVLVSGH DNNESNVQMQ VNLQTKSDPT
LSYNLLKLAN DELPFEETEP NDKGSEYENQ DNGRFSSSSN SSCSNSSNSS LKKTQDSINE
KLRNQRSQRY RVQSVEEETN RKRRGKNRKK RNIKENPPIK RIKISLNGTI SNLSSSNNSS
SSESETETGL ENENEVENDY ENNNDEEYAV VQRPTCGDGA SNNHIVMTIK KTPSKINSPA
NSMSATSPIN ASETRNVKNA FSDSNRPNLL TSSTSIAPLY QIDGGRRLLL SKKFSRRPHR
RRRYRQCRRK SDLQRKAIDL ELKHLFTYKT KPDLDIGSAI KLHKKLFFSH ELCKQNTAGR
KERILNYSSS SSSNYDDDES DLDGLSSEET AADLKENVNT FNKYNLNIET DNTSAERTVS
EDPLKIEEDP YLTSSSNDVT DSDNESDNHE VFDEVAKRVE ADEFNELHNN GMLTSFNSIS
VENQLINEPT LMAVSGSVDT PAPQSNASLA SLQNENCDDV NNLCYNNNNL DVIKHSLAAS
PILNDINYKN VISNTSPRVL ANKFSDCIPQ NIGNSELSPP IPLPCAEYQT GIRPAPLTDL
ALSSYADFRC TRIQQFKEWH QVLQLQSYNN EPLIVLPYVV LE
