ID   MED26_XENLA             Reviewed;         597 AA.
AC   Q90YY5;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 26;
DE   AltName: Full=Cofactor required for Sp1 transcriptional activation subunit 7;
DE            Short=CRSP complex subunit 7;
DE   AltName: Full=Mediator complex subunit 26;
GN   Name=med26; Synonyms=crsp7;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Hartmann E.;
RL   Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 26 family.
CC       {ECO:0000305}.
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DR   EMBL; AF395742; AAK83376.1; -; mRNA.
DR   EMBL; BC077251; AAH77251.1; -; mRNA.
DR   RefSeq; NP_001083898.1; NM_001090429.1.
DR   AlphaFoldDB; Q90YY5; -.
DR   SMR; Q90YY5; -.
DR   GeneID; 399180; -.
DR   KEGG; xla:399180; -.
DR   CTD; 399180; -.
DR   Xenbase; XB-GENE-1001807; med26.L.
DR   OMA; NMVVVLE; -.
DR   OrthoDB; 459216at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 399180; Expressed in ovary and 19 other tissues.
DR   GO; GO:0016592; C:mediator complex; ISS:UniProtKB.
DR   GO; GO:0003712; F:transcription coregulator activity; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   Gene3D; 1.20.930.10; -; 1.
DR   InterPro; IPR042376; MED26.
DR   InterPro; IPR031416; Med26_C.
DR   InterPro; IPR031417; Med26_Mid.
DR   InterPro; IPR003617; TFIIS/CRSP70_N_sub.
DR   InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR   InterPro; IPR017923; TFIIS_N.
DR   PANTHER; PTHR15201; PTHR15201; 1.
DR   Pfam; PF08711; Med26; 1.
DR   Pfam; PF15693; Med26_C; 1.
DR   Pfam; PF15694; Med26_M; 1.
DR   SMART; SM00509; TFS2N; 1.
DR   SUPFAM; SSF47676; SSF47676; 1.
DR   PROSITE; PS51319; TFIIS_N; 1.
PE   2: Evidence at transcript level;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..597
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   26"
FT                   /id="PRO_0000304961"
FT   DOMAIN          10..87
FT                   /note="TFIIS N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00649"
FT   REGION          96..236
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          254..418
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          436..459
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        262..315
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        346..385
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        386..403
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   597 AA;  65772 MW;  D5151A4FBB44CDDA CRC64;
     MTAAPVSPRE IRERLLQAID KQSNIQNMVA VLEVISSLEK YPITKEALEE TRLGKLINDV
     RKKTSNEDLA KRAKKLLRNW QKLIEPVTQN EQLVRGIPNL PGSANGGGSH NCKADPAPTN
     LLAGKPIQEL KGRNDIQKAH SPKADKTPKR KRKEHRDGGQ GTPGHLSKPN HELFQNSSPP
     PTNGIGGSPP DNLPSPLDGG LQSNNRLEPA ENDKHGKIPI NAVRPHTNSP GLVKHPSTSS
     LLKVVVLQQH SGGLDDALSH QPRSPRCSSF SPRGTRAELA TRQHTTYAPK GSAPSPSQRL
     PGVDSAHQSP LHPSTPPATA KRLESPRQDR VSSPHKPVEQ LPSTDCHQVL PRTSQQHIPR
     SSLVDSQTPR TGFSPESSKL DSDDAASGSD NLKRKKSRLR IECEGQSADG TGKPARVKKE
     RRLTFDVITG QIKPLTLKDP AQVESSAPTE QHRTETDKQD LTLSLPSPFQ LTNWKELSGN
     EIIQSYLHRQ SSLLSSSGIQ TQSAHYYMSE YLKQEECTKR ESRKTHVLVP IVLPSDLPGR
     TREITSSDTD RIQNQHWPGV NGCHDTQGNW YDWTQCISLD PHGDDGRLNI LPYVCLD