ID   MED27_AEDAE             Reviewed;         295 AA.
AC   Q171Y8;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 27;
DE   AltName: Full=Mediator complex subunit 27;
GN   Name=MED27; ORFNames=AAEL007482;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 27 family.
CC       {ECO:0000305}.
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DR   EMBL; CH477443; EAT40798.1; -; Genomic_DNA.
DR   RefSeq; XP_001652785.1; XM_001652735.1.
DR   AlphaFoldDB; Q171Y8; -.
DR   SMR; Q171Y8; -.
DR   STRING; 7159.AAEL007482-PA; -.
DR   GeneID; 5569226; -.
DR   KEGG; aag:5569226; -.
DR   VEuPathDB; VectorBase:AAEL007482; -.
DR   eggNOG; ENOG502QS6H; Eukaryota.
DR   HOGENOM; CLU_056015_0_0_1; -.
DR   InParanoid; Q171Y8; -.
DR   OMA; HAAMLHF; -.
DR   OrthoDB; 1256412at2759; -.
DR   PhylomeDB; Q171Y8; -.
DR   Proteomes; UP000008820; Chromosome 1.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   InterPro; IPR021627; Mediator_Med27.
DR   PANTHER; PTHR13130; PTHR13130; 2.
DR   Pfam; PF11571; Med27; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..295
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   27"
FT                   /id="PRO_0000305016"
SQ   SEQUENCE   295 AA;  34076 MW;  58483FF9D37D5F1E CRC64;
     MNLEPINNAL SHLRMLRSSV GQVFETLGNG VRAEHGEEGK EQKFLQELQE LLNGVNSNLR
     EFETCINDLT PPQAPFNLAN TAYLSLETNL ERQALYPHLV QSYKWHDKLH EYSTFASVLL
     QQNSLKRSYY TNTKRRRSLP SSHLATPQTV DNLIGSIHFP NMNLKIVRPF MTNAILHITI
     ARVLRAAVIL KGLLIEWVTV KGFDESLLDG VDEHWTVSRH QVFRKVQDHA HSAMLHFFSP
     TLPDLAIRSF ITWFRSYLTL FADPCKKCGK HLHNTLPPTW RDLRTLEPYH EECKQ