ID   MED27_ANOGA             Reviewed;         295 AA.
AC   Q7QCJ9;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 3.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 27;
DE   AltName: Full=Mediator complex subunit 27;
GN   Name=MED27; ORFNames=AGAP002664;
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7165;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST;
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA   Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA   Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA   Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA   Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA   Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA   Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA   Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA   Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA   Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA   Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA   McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA   O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA   Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA   Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA   Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA   Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA   Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA   Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA   Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 27 family.
CC       {ECO:0000305}.
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DR   EMBL; AAAB01008859; EAA08132.3; -; Genomic_DNA.
DR   RefSeq; XP_312260.3; XM_312260.4.
DR   AlphaFoldDB; Q7QCJ9; -.
DR   SMR; Q7QCJ9; -.
DR   STRING; 7165.AGAP002664-PA; -.
DR   PaxDb; Q7QCJ9; -.
DR   GeneID; 1273296; -.
DR   KEGG; aga:AgaP_AGAP002664; -.
DR   CTD; 1273296; -.
DR   VEuPathDB; VectorBase:AGAP002664; -.
DR   eggNOG; ENOG502QS6H; Eukaryota.
DR   HOGENOM; CLU_056015_0_0_1; -.
DR   InParanoid; Q7QCJ9; -.
DR   OMA; HAAMLHF; -.
DR   OrthoDB; 1256412at2759; -.
DR   PhylomeDB; Q7QCJ9; -.
DR   Proteomes; UP000007062; Chromosome 2R.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR021627; Mediator_Med27.
DR   PANTHER; PTHR13130; PTHR13130; 2.
DR   Pfam; PF11571; Med27; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..295
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   27"
FT                   /id="PRO_0000305017"
SQ   SEQUENCE   295 AA;  34021 MW;  5777DB5D3DE22180 CRC64;
     MNLEPINNAL SQLRVLRSSV GQVFETLGTG VRADHGEEGK EQKFLQELQE LLNSVNANLK
     DFESCINDLT PPQTPLTLAN SAYLSLETNL ERQALYPHLV QSYKWHDKLH EYSTFASTLL
     QQNSLKRSYY TNTKRRRSLP SSHLATPQMV ENLIGSIHYN NMNLKIARPF MTNAILHITI
     ARVLRAAVIL KGLLIEWVTV KGYEESLLDG VDEQWTESRH QVFRKVQDHA HSAMLHFFSP
     TLPELAIRSF ITWFRSYVTL FADPCKKCGK HLHNTLPPTW RDLRTLEPFH EECKQ