ID   MED28_XENTR             Reviewed;         169 AA.
AC   A4IIZ9;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 28;
DE   AltName: Full=Mediator complex subunit 28;
GN   Name=med28;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 28 family.
CC       {ECO:0000305}.
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DR   EMBL; BC136218; AAI36219.1; -; mRNA.
DR   RefSeq; NP_001096476.1; NM_001103006.1.
DR   AlphaFoldDB; A4IIZ9; -.
DR   SMR; A4IIZ9; -.
DR   PaxDb; A4IIZ9; -.
DR   DNASU; 100125095; -.
DR   GeneID; 100125095; -.
DR   KEGG; xtr:100125095; -.
DR   CTD; 80306; -.
DR   Xenbase; XB-GENE-961728; med28.
DR   eggNOG; ENOG502QSN9; Eukaryota.
DR   HOGENOM; CLU_129063_0_0_1; -.
DR   InParanoid; A4IIZ9; -.
DR   OrthoDB; 1504193at2759; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   InterPro; IPR021640; Mediator_Med28.
DR   PANTHER; PTHR13512; PTHR13512; 1.
PE   2: Evidence at transcript level;
KW   Activator; Coiled coil; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..169
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   28"
FT                   /id="PRO_0000305697"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          99..137
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..19
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   169 AA;  18801 MW;  F4AC8941EFB34ED7 CRC64;
     MFSAQQPGPP PPNQPGAPAG LMSTPPGAKN PSSTLVDDLE SSFEACFASL VSQDYVNGTD
     QEEIRTGVEQ CIQKFLDVAR QTECFFLQKR LQLSVQKPEQ VIKEDVSELR NELQRKEALI
     QKHLTKLRSW QQVLEEINGQ HKKTSEMPQG PLAYLEQASA NIPAPMKPT