ID   MED29_AEDAE             Reviewed;         214 AA.
AC   Q16TJ7;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 29;
DE   AltName: Full=Mediator complex subunit 29;
DE   AltName: Full=Protein intersex;
GN   Name=ix; Synonyms=MED29; ORFNames=AAEL010217;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 29 family.
CC       {ECO:0000305}.
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DR   EMBL; CH477648; EAT37824.1; -; Genomic_DNA.
DR   RefSeq; XP_001654364.1; XM_001654314.1.
DR   AlphaFoldDB; Q16TJ7; -.
DR   SMR; Q16TJ7; -.
DR   STRING; 7159.AAEL010217-PB; -.
DR   PRIDE; Q16TJ7; -.
DR   GeneID; 5573044; -.
DR   KEGG; aag:5573044; -.
DR   VEuPathDB; VectorBase:AAEL010217; -.
DR   eggNOG; ENOG502QRNJ; Eukaryota.
DR   HOGENOM; CLU_101133_0_0_1; -.
DR   InParanoid; Q16TJ7; -.
DR   OMA; MPDNAGP; -.
DR   OrthoDB; 1480686at2759; -.
DR   PhylomeDB; Q16TJ7; -.
DR   Proteomes; UP000008820; Chromosome 3.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   InterPro; IPR021018; Mediator_Med29_met.
DR   PANTHER; PTHR28314; PTHR28314; 1.
DR   Pfam; PF11568; Med29; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..214
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   29"
FT                   /id="PRO_0000305700"
FT   REGION          1..78
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        39..78
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   214 AA;  23074 MW;  07B33C0AA4E78D63 CRC64;
     MMNQMGMHMQ QPGVVPGGPG GPVGMAGGPV GGVGVSPVMM QSPQMQQQQQ VAAQQQQQQQ
     QQQQAQAHQQ QSQQTEKVDN ISKVKGLVGP LRDSLSTTVK TAAQLLQQNN LNDAGTKGGD
     MSTTTPRFDK HLEEFYSICD QIELNLKTAK LCMQQGASSQ QYLPIPVAPT QPNPAETNAL
     SYSQYLDVVK IQIGYAKDIH DTLICAAQNI CPSE