ID   MED29_BOMMO             Reviewed;         192 AA.
AC   Q5ISW3;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 29;
DE   AltName: Full=Mediator complex subunit 29;
DE   AltName: Full=Protein intersex;
GN   Name=ix; Synonyms=MED29;
OS   Bombyx mori (Silk moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Bombycidae; Bombycinae; Bombyx.
OX   NCBI_TaxID=7091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=15645316; DOI=10.1007/s00427-004-0445-x;
RA   Siegal M.L., Baker B.S.;
RT   "Functional conservation and divergence of intersex, a gene required for
RT   female differentiation in Drosophila melanogaster.";
RL   Dev. Genes Evol. 215:1-12(2005).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 29 family.
CC       {ECO:0000305}.
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DR   EMBL; AY648340; AAV65896.1; -; mRNA.
DR   RefSeq; NP_001037105.1; NM_001043640.1.
DR   AlphaFoldDB; Q5ISW3; -.
DR   SMR; Q5ISW3; -.
DR   STRING; 7091.BGIBMGA010131-TA; -.
DR   GeneID; 692650; -.
DR   KEGG; bmor:692650; -.
DR   CTD; 45881; -.
DR   eggNOG; ENOG502QRNJ; Eukaryota.
DR   HOGENOM; CLU_101133_0_0_1; -.
DR   InParanoid; Q5ISW3; -.
DR   OrthoDB; 1396750at2759; -.
DR   Proteomes; UP000005204; Unassembled WGS sequence.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   InterPro; IPR021018; Mediator_Med29_met.
DR   PANTHER; PTHR28314; PTHR28314; 1.
DR   Pfam; PF11568; Med29; 1.
PE   2: Evidence at transcript level;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..192
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   29"
FT                   /id="PRO_0000305702"
FT   REGION          32..51
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   192 AA;  21260 MW;  AEDCF91C774F74BB CRC64;
     MNHNQMNMHV PMNQVAGAPN VAMQMPVPGP IMQQQSPQQM QPAPVPQQTQ QDKMDNISKV
     KSLMGSLRES IPMTLKSAAQ ILHQNHNADS NTQKGMDNPV PRFEKNLEEF FSICDQMELH
     LRTATTCIQQ AQSAAHYLPL SVIASRLDSG PTTQETTLSY PQYLKTVGLQ ISYAKDIHDT
     LVAAAQNISP PE