ID   MED29_BOVIN             Reviewed;         200 AA.
AC   A1A4Q8;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 29;
DE   AltName: Full=Intersex-like protein;
DE   AltName: Full=Mediator complex subunit 29;
GN   Name=MED29; Synonyms=IXL;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal medulla;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the mediator complex, a complex that can either
CC       repress or activate transcription. Mediator complexes are essential for
CC       basal and regulated expression of nearly all RNA polymerase II-
CC       dependent genes. They may act as a bridge, conveying regulatory
CC       information from enhancers and other control elements to the promoter
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the TRAP/SMCC mediator complex. Interacts with
CC       MED20/TRFP. Associates with the MED18-MED20 heteromer (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 29 family.
CC       {ECO:0000305}.
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DR   EMBL; BC126813; AAI26814.1; -; mRNA.
DR   RefSeq; NP_001073785.1; NM_001080316.2.
DR   AlphaFoldDB; A1A4Q8; -.
DR   SMR; A1A4Q8; -.
DR   STRING; 9913.ENSBTAP00000027226; -.
DR   PaxDb; A1A4Q8; -.
DR   PRIDE; A1A4Q8; -.
DR   GeneID; 614626; -.
DR   KEGG; bta:614626; -.
DR   CTD; 55588; -.
DR   eggNOG; ENOG502QRNJ; Eukaryota.
DR   HOGENOM; CLU_101133_2_0_1; -.
DR   InParanoid; A1A4Q8; -.
DR   OMA; MPDNAGP; -.
DR   OrthoDB; 1480686at2759; -.
DR   TreeFam; TF326632; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR021018; Mediator_Med29_met.
DR   PANTHER; PTHR28314; PTHR28314; 1.
DR   Pfam; PF11568; Med29; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NX70"
FT   CHAIN           2..200
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   29"
FT                   /id="PRO_0000288057"
FT   REGION          1..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NX70"
SQ   SEQUENCE   200 AA;  21151 MW;  FEA526AAF3DF4EC6 CRC64;
     MAASQQQASA TTSTASVSGP GSAGGSGPQQ QPQPPAQLVG PAQSGLLQQQ QQDFDPVQRY
     KMLIPQLKES LQTLMKVAAQ NLIQNTNIDN GQKSSDGPIQ RFDKCLEEFY ALCDQLELCL
     RLAHECLSQS CDSAKHSPTL VPTATKPDAV QPDSLPYPQY LAVIKAQIAC AKDIHTALLD
     CANKVTGKTP APPTGPGGTL