ID   MED29_CAEBR             Reviewed;         473 AA.
AC   Q60YF6; A8XSA0;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-NOV-2009, sequence version 3.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 29;
DE   AltName: Full=Mediator complex subunit 29;
GN   Name=mdt-29; ORFNames=CBG18261;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 29 family.
CC       {ECO:0000305}.
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DR   EMBL; HE600936; CAP35742.3; -; Genomic_DNA.
DR   AlphaFoldDB; Q60YF6; -.
DR   STRING; 6238.CBG18261; -.
DR   WormBase; CBG18261; CBP40730; WBGene00037712; Cbr-mdt-29.
DR   eggNOG; ENOG502S549; Eukaryota.
DR   HOGENOM; CLU_597499_0_0_1; -.
DR   InParanoid; Q60YF6; -.
DR   OMA; GEMANVN; -.
DR   OrthoDB; 1339572at2759; -.
DR   Proteomes; UP000008549; Chromosome III.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR021018; Mediator_Med29_met.
DR   Pfam; PF11568; Med29; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..473
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   29"
FT                   /id="PRO_0000305705"
FT   REGION          1..319
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          444..473
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..88
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        107..122
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        146..182
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        198..232
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        239..283
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        447..464
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   473 AA;  51147 MW;  69D3A819FD848FCF CRC64;
     MSGQGPPSNL TPQQQHMIMQ QQQQQQMMRQ QQIQQQQLHQ RQLQQQQAQQ SYQRSRTPQM
     QQHPGGGSPG SHLQMHPHLQ SQGHMQPRSP LVGQHHPAPG SIPPGNPATP QMMQQQMGMN
     QPMSLPAPHV SRPGSVAPPA SVPPNMHTGP SSNQMDQMGG QSQYSHHLQP QQPLSRPGSQ
     QSHIAGGHGG PHSVQQPGSV LAPGSIQQPG SLLAPGSMHQ PGSVQQPGSL GAPLSHTGAG
     GPQSVQGYGP GSVQPPGSAQ APSSVQPGST FAPGSLQAPA SQQPPASIQP PPSAASGSVA
     GPASAAPAKV EPLKPNEEQI RMVQDPVDLV RNLVQKDLRM SVVEMNKRGA ELLHQKEEGA
     IKEEDRQQYK RATNDFHAVC DEIDRTLTTI METAKQITKL DKVFQDRTSK EIDGEAMVNS
     VQKFVDETGI VQKMFDDTVN SVTSTMEKMR RRQKKWKDQQ QQQENAEDAE MAE