MED29_DANRE
ID MED29_DANRE Reviewed; 179 AA.
AC Q8JHI6;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 29;
DE AltName: Full=Intersex-like protein;
DE AltName: Full=Mediator complex subunit 29;
GN Name=med29; Synonyms=ixl;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12006978; DOI=10.1038/ng896;
RA Golling G., Amsterdam A., Sun Z., Antonelli M., Maldonado E., Chen W.,
RA Burgess S., Haldi M., Artzt K., Farrington S., Lin S.-Y., Nissen R.M.,
RA Hopkins N.;
RT "Insertional mutagenesis in zebrafish rapidly identifies genes essential
RT for early vertebrate development.";
RL Nat. Genet. 31:135-140(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 29 family.
CC {ECO:0000305}.
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DR EMBL; AF506210; AAM34654.1; -; mRNA.
DR EMBL; BC094992; AAH94992.1; -; mRNA.
DR RefSeq; NP_775378.1; NM_173271.1.
DR AlphaFoldDB; Q8JHI6; -.
DR SMR; Q8JHI6; -.
DR STRING; 7955.ENSDARP00000031379; -.
DR PaxDb; Q8JHI6; -.
DR Ensembl; ENSDART00000033904; ENSDARP00000031379; ENSDARG00000026448.
DR Ensembl; ENSDART00000181916; ENSDARP00000151522; ENSDARG00000109733.
DR GeneID; 797134; -.
DR KEGG; dre:797134; -.
DR CTD; 55588; -.
DR ZFIN; ZDB-GENE-021217-1; med29.
DR eggNOG; ENOG502QRNJ; Eukaryota.
DR GeneTree; ENSGT00940000164885; -.
DR HOGENOM; CLU_101133_2_0_1; -.
DR InParanoid; Q8JHI6; -.
DR OMA; MPDNAGP; -.
DR OrthoDB; 1480686at2759; -.
DR PhylomeDB; Q8JHI6; -.
DR TreeFam; TF326632; -.
DR PRO; PR:Q8JHI6; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 15.
DR Bgee; ENSDARG00000026448; Expressed in ovary and 23 other tissues.
DR ExpressionAtlas; Q8JHI6; baseline.
DR GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR GO; GO:0042462; P:eye photoreceptor cell development; IMP:ZFIN.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR021018; Mediator_Med29_met.
DR PANTHER; PTHR28314; PTHR28314; 1.
DR Pfam; PF11568; Med29; 1.
PE 2: Evidence at transcript level;
KW Activator; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..179
FT /note="Mediator of RNA polymerase II transcription subunit
FT 29"
FT /id="PRO_0000288061"
SQ SEQUENCE 179 AA; 19705 MW; 812E4FDE1D4EBD72 CRC64;
MASQQMSTNN AQMSAQQAAV LQQTQAQQLS QQQDFDPVHR FKMLIPPLKD SLQNVMTIAS
LNFAHNTAID NGLKTTEKGN DAAVQRFDKS LEEFYALCDQ LELCLRLAHE CLSQSIDSTK
HSPNLVPTAT KPDTVQTESL SYSQYLSMIK SQISCAKDIH NALLECSKKI AGKGQGACN
