ID   MED29_DICDI             Reviewed;         554 AA.
AC   Q54PD9;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JAN-2010, sequence version 2.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Putative mediator of RNA polymerase II transcription subunit 29;
DE   AltName: Full=Putative mediator complex subunit 2;
DE   AltName: Full=Putative mediator complex subunit 29;
DE   AltName: Full=Putative mediator of RNA polymerase II transcription subunit 2;
GN   Name=med29; Synonyms=med2; ORFNames=DDB_G0284719;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=18515835; DOI=10.1093/nar/gkn349;
RA   Bourbon H.-M.;
RT   "Comparative genomics supports a deep evolutionary origin for the large,
RT   four-module transcriptional mediator complex.";
RL   Nucleic Acids Res. 36:3993-4008(2008).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 29 family.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000070; EAL65129.2; -; Genomic_DNA.
DR   RefSeq; XP_638436.2; XM_633344.2.
DR   AlphaFoldDB; Q54PD9; -.
DR   STRING; 44689.DDB0266840; -.
DR   PaxDb; Q54PD9; -.
DR   EnsemblProtists; EAL65129; EAL65129; DDB_G0284719.
DR   GeneID; 8624686; -.
DR   KEGG; ddi:DDB_G0284719; -.
DR   dictyBase; DDB_G0284719; med29.
DR   HOGENOM; CLU_492137_0_0_1; -.
DR   InParanoid; Q54PD9; -.
DR   OMA; EAPMEIS; -.
DR   PRO; PR:Q54PD9; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0016592; C:mediator complex; ISS:dictyBase.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; ISS:dictyBase.
PE   3: Inferred from homology;
KW   Activator; Coiled coil; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..554
FT                   /note="Putative mediator of RNA polymerase II transcription
FT                   subunit 29"
FT                   /id="PRO_0000350814"
FT   REGION          118..301
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          330..381
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          398..428
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          483..524
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          167..194
FT                   /evidence="ECO:0000255"
FT   COILED          419..486
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        483..519
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   554 AA;  62653 MW;  14FE75B297890F5D CRC64;
     MNLDSLSKII KNKIQNVLYP TSKALLSSDD PSKRAETCYD LSQKIEEFEL VCDELYGIIE
     IHKQNVIFSN INNGTHISKE NNPEVLFNSL VSRLSTLRQT KSTMDSFAKE ISIVQPIDNK
     ANTNNNNNNN NNNNNNNNNN NNNNNNTNTN TNNTNNTNNT TNTNNTNNNN NNNYNNNNNN
     NNNNNNNNNN NNNNNNNNSI NNSINNNSNN KVGSNDNPST APITENNTEN NAGNTNNTNN
     NNNNNNNNNN NNNNNNNNNN NNTNQVAESS NISSNTTPPE TTNIVNDPNS VSGGNLTNTE
     APMEISDNSE IQHPQQEQQQ QQQQQQQQQQ QQQQQQQQPQ EQIPQQQQPQ LPMQQEQIQQ
     LPQQQTPPSQ QQPQQTPPLP QQFQQPLVNV NQITSPTLEN QSISGNNNNN NDGQTISPQQ
     QQEQLQLQMQ QLQQLQMQQQ QMNFNPTEPI NTNFYNIDLQ QPIQQQTLNN NNNNINSLEN
     QINTNLGGNT FNTGTTPPLQ QQPQPQQQQQ INNPEINQID DDNTMKETID VDKIIEESNN
     VNNNVNNRQV IDLE