ID   MED29_DROVI             Reviewed;         205 AA.
AC   Q5ISW5; B4LQ59; Q5ISV2;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 29;
DE   AltName: Full=Mediator complex subunit 29;
DE   AltName: Full=Protein intersex;
GN   Name=ix; Synonyms=MED29; ORFNames=GJ21983;
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND NUCLEOTIDE SEQUENCE [MRNA] OF 9-199.
RX   PubMed=15645316; DOI=10.1007/s00427-004-0445-x;
RA   Siegal M.L., Baker B.S.;
RT   "Functional conservation and divergence of intersex, a gene required for
RT   female differentiation in Drosophila melanogaster.";
RL   Dev. Genes Evol. 215:1-12(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15010-1051.87;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 29 family.
CC       {ECO:0000305}.
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DR   EMBL; AY648338; AAV65894.1; -; Genomic_DNA.
DR   EMBL; AY649563; AAV65946.1; -; mRNA.
DR   EMBL; CH940648; EDW61344.1; -; Genomic_DNA.
DR   RefSeq; XP_002050151.1; XM_002050115.2.
DR   AlphaFoldDB; Q5ISW5; -.
DR   SMR; Q5ISW5; -.
DR   STRING; 7244.FBpp0236400; -.
DR   EnsemblMetazoa; FBtr0237908; FBpp0236400; FBgn0209097.
DR   GeneID; 6625475; -.
DR   KEGG; dvi:6625475; -.
DR   eggNOG; ENOG502QRNJ; Eukaryota.
DR   HOGENOM; CLU_101133_0_0_1; -.
DR   InParanoid; Q5ISW5; -.
DR   OMA; MPDNAGP; -.
DR   OrthoDB; 1480686at2759; -.
DR   PhylomeDB; Q5ISW5; -.
DR   Proteomes; UP000008792; Unassembled WGS sequence.
DR   GO; GO:0016592; C:mediator complex; ISS:UniProtKB.
DR   GO; GO:0003712; F:transcription coregulator activity; ISS:UniProtKB.
DR   GO; GO:0035263; P:genital disc sexually dimorphic development; IEA:EnsemblMetazoa.
DR   GO; GO:0048804; P:imaginal disc-derived female genitalia morphogenesis; IEA:EnsemblMetazoa.
DR   GO; GO:0060548; P:negative regulation of cell death; IEA:EnsemblMetazoa.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0007530; P:sex determination; IEA:EnsemblMetazoa.
DR   InterPro; IPR021018; Mediator_Med29_met.
DR   PANTHER; PTHR28314; PTHR28314; 1.
DR   Pfam; PF11568; Med29; 1.
PE   2: Evidence at transcript level;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..205
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   29"
FT                   /id="PRO_0000305704"
FT   REGION          1..65
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..26
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        39..65
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        44
FT                   /note="H -> HQ (in Ref. 1; AAV65946)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   205 AA;  23200 MW;  F2801B962017433B CRC64;
     MNPNMNMMQM SGPPMMQVSP MMQSSPQPMM PTGPPGPVPM QQQHQQQQQQ QQQQQQQQQQ
     QAEKLDNISR VKSLLGPLRE SMFLTIRSSA FTLQQNNLAD NLKRDTGGHG HVPRFDKHLE
     DFYACCDQME LHLKTAIQCM QQLTSSQHYL PGAVTAMRME NFMQDNPAGP IPYPTYLNTV
     RVHVQSAKDI HDTLISAAQN ISQAD