ID   MED29_XENLA             Reviewed;         186 AA.
AC   Q66KX4;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 29;
DE   AltName: Full=Intersex-like protein;
DE   AltName: Full=Mediator complex subunit 29;
GN   Name=med29; Synonyms=ixl;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 29 family.
CC       {ECO:0000305}.
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DR   EMBL; BC078525; AAH78525.1; -; mRNA.
DR   RefSeq; NP_001087298.1; NM_001093829.1.
DR   AlphaFoldDB; Q66KX4; -.
DR   SMR; Q66KX4; -.
DR   MaxQB; Q66KX4; -.
DR   DNASU; 447120; -.
DR   GeneID; 447120; -.
DR   KEGG; xla:447120; -.
DR   CTD; 447120; -.
DR   Xenbase; XB-GENE-6254344; med29.L.
DR   OMA; MPDNAGP; -.
DR   OrthoDB; 1480686at2759; -.
DR   Proteomes; UP000186698; Chromosome 8L.
DR   Bgee; 447120; Expressed in oocyte and 19 other tissues.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   InterPro; IPR021018; Mediator_Med29_met.
DR   PANTHER; PTHR28314; PTHR28314; 1.
DR   Pfam; PF11568; Med29; 1.
PE   2: Evidence at transcript level;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..186
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   29"
FT                   /id="PRO_0000288062"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..19
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   186 AA;  20430 MW;  7BD7FED3A3FC16E5 CRC64;
     MAMLLNQAQP PQTRDGGGTQ GASLGPGVPV GQQQLGLQQQ QQDFDPVQRY RMLIPQLKES
     LQNLMKIAAQ NLAQNTNIDN GQKSADGPVQ RFDKSLEEFY ALCDQMELCL RLAYECLSQS
     YDSAKHSPTL VPTATKPDAV QTESLPYTQY LSMIKSQISC AKDIHNALLE CSKKIMGKTP
     NTQGGL