ID   MED29_XENTR             Reviewed;         188 AA.
AC   Q08D01;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 29;
DE   AltName: Full=Intersex-like protein;
DE   AltName: Full=Mediator complex subunit 29;
GN   Name=med29; Synonyms=ixl;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=N6; TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 29 family.
CC       {ECO:0000305}.
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DR   EMBL; BC124010; AAI24011.1; -; mRNA.
DR   RefSeq; NP_001072872.1; NM_001079404.1.
DR   AlphaFoldDB; Q08D01; -.
DR   SMR; Q08D01; -.
DR   STRING; 8364.ENSXETP00000057016; -.
DR   DNASU; 780334; -.
DR   GeneID; 780334; -.
DR   KEGG; xtr:780334; -.
DR   CTD; 55588; -.
DR   Xenbase; XB-GENE-1006668; med29.
DR   eggNOG; ENOG502QRNJ; Eukaryota.
DR   InParanoid; Q08D01; -.
DR   OrthoDB; 1480686at2759; -.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR021018; Mediator_Med29_met.
DR   PANTHER; PTHR28314; PTHR28314; 1.
DR   Pfam; PF11568; Med29; 1.
PE   2: Evidence at transcript level;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..188
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   29"
FT                   /id="PRO_0000288063"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..16
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   188 AA;  20768 MW;  E8A1EA2CF5ECF07D CRC64;
     MAMLLNQSQP PQGREGGGTQ VGSLGPGIPV GQQQQQLGLQ QQQQDFDPVQ RYRMLIPQLK
     ESLQNLMKIA AQNLVQNTNI DNGQKNADGL VQRFDKSLEE FYAICDQLEL CLRLAYECLS
     QSYDSAKHSP TLVPTATKPD AVQTESLPYT QYLSMIKSQI SCAKDIHNAL LECSKKIMGK
     TPNTQGGL