ID   MED2_KLULA              Reviewed;         280 AA.
AC   Q6CJZ6;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 2;
DE   AltName: Full=Mediator complex subunit 2;
GN   Name=MED2; OrderedLocusNames=KLLA0F14751g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 2 family.
CC       {ECO:0000305}.
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DR   EMBL; CR382126; CAG98451.1; -; Genomic_DNA.
DR   RefSeq; XP_455743.1; XM_455743.1.
DR   AlphaFoldDB; Q6CJZ6; -.
DR   STRING; 28985.XP_455743.1; -.
DR   EnsemblFungi; CAG98451; CAG98451; KLLA0_F14751g.
DR   GeneID; 2894780; -.
DR   KEGG; kla:KLLA0_F14751g; -.
DR   eggNOG; ENOG502RZB6; Eukaryota.
DR   HOGENOM; CLU_046031_0_0_1; -.
DR   InParanoid; Q6CJZ6; -.
DR   OMA; AEMMMQQ; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR021017; Mediator_Med2_fun.
DR   Pfam; PF11214; Med2; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..280
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   2"
FT                   /id="PRO_0000302015"
FT   REGION          212..247
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   280 AA;  31890 MW;  452751AA710FA6C4 CRC64;
     MVPKTGVSDR QENKLTQYFD DILRLSADLL TQQQLKTIKL DPKVTTGFSK AQQKGLGDRI
     TQFYSLLDTL DVSLQTTADY VGAVKDSALQ LKKQREEEQI KKQEQEKLER QLLEQQKLEQ
     QQLEQKQLKQ KQQQQQQQQQ QQQQQQPQEQ QHEQQQRYSA KNTPIDMLTN FDTDLPSAGI
     TQAQSFNSEF GDLNGMDLSM FDSMDNQVGF GGLQNTSGGN EKKNDPQINF NDTNAPPSAV
     NVPENGNPSS YLTLNDFNDL GIDWNAANDN NELNLEDFNI