MED30_BOVIN
ID MED30_BOVIN Reviewed; 193 AA.
AC Q2YDF2;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 30;
DE AltName: Full=Mediator complex subunit 30;
DE AltName: Full=Thyroid hormone receptor-associated protein 6;
DE AltName: Full=Thyroid hormone receptor-associated protein complex 25 kDa component;
DE Short=Trap25;
GN Name=MED30; Synonyms=THRAP6, TRAP25;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the Mediator complex, which is composed of MED1,
CC MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L,
CC MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23,
CC MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and
CC CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
CC module termed the CDK8 module. Mediator containing the CDK8 module is
CC less active than Mediator lacking this module in supporting
CC transcriptional activation. Individual preparations of the Mediator
CC complex lacking one or more distinct subunits have been variously
CC termed ARC, CRSP, DRIP, PC2, SMCC and TRAP (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 30 family.
CC {ECO:0000305}.
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DR EMBL; BC110250; AAI10251.1; -; mRNA.
DR RefSeq; NP_001073086.1; NM_001079618.2.
DR AlphaFoldDB; Q2YDF2; -.
DR SMR; Q2YDF2; -.
DR STRING; 9913.ENSBTAP00000009150; -.
DR PaxDb; Q2YDF2; -.
DR Ensembl; ENSBTAT00000084060; ENSBTAP00000073342; ENSBTAG00000026254.
DR GeneID; 613879; -.
DR KEGG; bta:613879; -.
DR CTD; 90390; -.
DR VEuPathDB; HostDB:ENSBTAG00000026254; -.
DR VGNC; VGNC:31366; MED30.
DR eggNOG; ENOG502QV3C; Eukaryota.
DR GeneTree; ENSGT00390000010887; -.
DR HOGENOM; CLU_074190_1_1_1; -.
DR InParanoid; Q2YDF2; -.
DR OrthoDB; 1549016at2759; -.
DR TreeFam; TF324588; -.
DR Proteomes; UP000009136; Chromosome 14.
DR Bgee; ENSBTAG00000026254; Expressed in oocyte and 106 other tissues.
DR ExpressionAtlas; Q2YDF2; baseline.
DR GO; GO:0070847; C:core mediator complex; IEA:Ensembl.
DR GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR GO; GO:0046966; F:nuclear thyroid hormone receptor binding; IEA:Ensembl.
DR GO; GO:0003713; F:transcription coactivator activity; IEA:Ensembl.
DR GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR GO; GO:0060261; P:positive regulation of transcription initiation from RNA polymerase II promoter; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0035019; P:somatic stem cell population maintenance; IEA:Ensembl.
DR InterPro; IPR021019; Mediator_Med30_met.
DR PANTHER; PTHR31705; PTHR31705; 1.
DR Pfam; PF11315; Med30; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Activator; Coiled coil; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q96HR3"
FT CHAIN 2..193
FT /note="Mediator of RNA polymerase II transcription subunit
FT 30"
FT /id="PRO_0000239405"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 71..93
FT /evidence="ECO:0000255"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0000250|UniProtKB:Q96HR3"
SQ SEQUENCE 193 AA; 21691 MW; 9CE39BBEB1487A59 CRC64;
MSTPPLAASG MAPGPFAGPQ AQQAAREVNT ASLCRIGQET VQDIVYRTME IFQLLRNMQL
PNGVTYHTGT YQDRLAKLQD HLRQLSILFR KLRLVYDKCN ENCGGMDPIP VEQLIPYVEE
DGSKDDRAGP PRFASEERRE IAEVNKFQVN SKGTQPYLHM YPFSSKLPSH SGCRIPLSRI
PCAVQNSNRR INS