ID   MED30_DANRE             Reviewed;         174 AA.
AC   Q6PC45;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 30;
DE   AltName: Full=Mediator complex subunit 30;
DE   AltName: Full=Thyroid hormone receptor-associated protein 6 homolog;
GN   Name=med30; Synonyms=thrap6; ORFNames=zgc:73113;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 30 family.
CC       {ECO:0000305}.
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DR   EMBL; BC059478; AAH59478.1; -; mRNA.
DR   RefSeq; NP_957011.1; NM_200717.1.
DR   AlphaFoldDB; Q6PC45; -.
DR   SMR; Q6PC45; -.
DR   STRING; 7955.ENSDARP00000039524; -.
DR   PaxDb; Q6PC45; -.
DR   GeneID; 393690; -.
DR   KEGG; dre:393690; -.
DR   CTD; 90390; -.
DR   ZFIN; ZDB-GENE-040426-1676; med30.
DR   eggNOG; ENOG502QV3C; Eukaryota.
DR   InParanoid; Q6PC45; -.
DR   OrthoDB; 1549016at2759; -.
DR   PhylomeDB; Q6PC45; -.
DR   Reactome; R-DRE-212436; Generic Transcription Pathway.
DR   PRO; PR:Q6PC45; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
DR   InterPro; IPR021019; Mediator_Med30_met.
DR   PANTHER; PTHR31705; PTHR31705; 1.
DR   Pfam; PF11315; Med30; 1.
PE   2: Evidence at transcript level;
KW   Activator; Coiled coil; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..174
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   30"
FT                   /id="PRO_0000305907"
FT   COILED          113..166
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   174 AA;  20201 MW;  9C5B185045E3A524 CRC64;
     MTTPPLAQFS GQQQQQTQAA RDVNTASLCR IGQETVQDIV LRTMEIFQLL RNMQLPNGVT
     YHPNTHQDRL GKLQEHLRTL SVLFRKLRLV YDKCNENCAG LEPIPSEQLI PYVEDDSSKL
     EDRMANQLRA ASEERREVLE VNKKLKQKNQ QLKMIMDQLR NLIWEINSML AVRS