ID   MED30_XENLA             Reviewed;         184 AA.
AC   Q0IHI6;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 47.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 30;
DE   AltName: Full=Mediator complex subunit 30;
GN   Name=med30;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 30 family.
CC       {ECO:0000305}.
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DR   EMBL; BC123139; AAI23140.1; -; mRNA.
DR   RefSeq; NP_001090307.1; NM_001096838.1.
DR   AlphaFoldDB; Q0IHI6; -.
DR   SMR; Q0IHI6; -.
DR   MaxQB; Q0IHI6; -.
DR   DNASU; 779216; -.
DR   GeneID; 779216; -.
DR   KEGG; xla:779216; -.
DR   CTD; 779216; -.
DR   Xenbase; XB-GENE-1008117; med30.S.
DR   OMA; KHDDRGV; -.
DR   OrthoDB; 1549016at2759; -.
DR   Proteomes; UP000186698; Chromosome 6S.
DR   Bgee; 779216; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR021019; Mediator_Med30_met.
DR   PANTHER; PTHR31705; PTHR31705; 1.
DR   Pfam; PF11315; Med30; 1.
PE   2: Evidence at transcript level;
KW   Activator; Coiled coil; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..184
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   30"
FT                   /id="PRO_0000305908"
FT   COILED          136..179
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   184 AA;  20871 MW;  625441E59B202312 CRC64;
     MSTPPLSGPG MGAAAGPGGF PGAQAATAAR EVNTASLCRI GQETVQDIVF RTMEIFQLLR
     NMQLPNGVTY HTVTYQDRLG KLQEHLRQLS ILFRKLRLVY DKCNENCAGL DPVPIEQLIP
     YVEEEYSKHD DRGIASQLRF ASEEKREILE VNKKLKQKNQ QLKQIMDQLR NLIWDINSML
     AMRN