ID   MED31_CAEBR             Reviewed;         168 AA.
AC   Q61DP3; A8XFC7;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 2.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 31;
DE   AltName: Full=Mediator complex subunit 31;
DE   AltName: Full=Mediator complex subunit soh-1;
GN   Name=mdt-31; Synonyms=soh-1; ORFNames=CBG12403;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 31 family.
CC       {ECO:0000305}.
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DR   EMBL; HE600913; CAP31388.2; -; Genomic_DNA.
DR   AlphaFoldDB; Q61DP3; -.
DR   SMR; Q61DP3; -.
DR   STRING; 6238.CBG12403; -.
DR   WormBase; CBG12403; CBP17441; WBGene00033358; Cbr-mdt-31.
DR   eggNOG; KOG4086; Eukaryota.
DR   HOGENOM; CLU_071681_5_1_1; -.
DR   InParanoid; Q61DP3; -.
DR   OMA; KRHRLCM; -.
DR   OrthoDB; 1480492at2759; -.
DR   Proteomes; UP000008549; Chromosome I.
DR   GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.10.1340; -; 1.
DR   InterPro; IPR038089; Med31_sf.
DR   InterPro; IPR008831; Mediator_Med31.
DR   PANTHER; PTHR13186; PTHR13186; 1.
DR   Pfam; PF05669; Med31; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..168
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   31"
FT                   /id="PRO_0000305712"
FT   REGION          113..168
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        115..158
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   168 AA;  20031 MW;  98A4A445EC14E317 CRC64;
     METPESEKTR FEVECEFVQA LANPNYLNFL AQRGYFKEEY FVNYLKYLLY WKNPQYARCL
     KFPQCLHMLE ALQSQQFRDA MAYGPSAKFV EDQVVLQWQF YLRKRHRLCM LPEGEDQDVE
     ESEEETVENE QKESEDEEDV VIVEKPEDEQ EEQAEEAAEP TDTSLLNT