ID   MED31_CAEEL             Reviewed;         178 AA.
AC   P91869; I2HAC0;
DT   31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   02-DEC-2020, sequence version 2.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 31;
DE   AltName: Full=Mediator complex subunit 31;
DE   AltName: Full=Mediator complex subunit soh-1;
GN   Name=mdt-31 {ECO:0000312|WormBase:F32H2.2b};
GN   Synonyms=soh-1 {ECO:0000250|UniProtKB:P38633};
GN   ORFNames=F32H2.2 {ECO:0000312|WormBase:F32H2.2b};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=b {ECO:0000312|WormBase:F32H2.2b};
CC         IsoId=P91869-1; Sequence=Displayed;
CC       Name=a {ECO:0000312|WormBase:F32H2.2a};
CC         IsoId=P91869-2; Sequence=VSP_060782;
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 31 family.
CC       {ECO:0000305}.
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DR   EMBL; BX284601; CAB04242.1; -; Genomic_DNA.
DR   EMBL; BX284601; CCH63827.1; -; Genomic_DNA.
DR   PIR; T21674; T21674.
DR   RefSeq; NP_001250947.1; NM_001264018.1. [P91869-1]
DR   RefSeq; NP_001250948.1; NM_001264019.1. [P91869-2]
DR   RefSeq; NP_001250949.1; NM_001264020.1.
DR   AlphaFoldDB; P91869; -.
DR   SMR; P91869; -.
DR   BioGRID; 49990; 1.
DR   IntAct; P91869; 1.
DR   STRING; 6239.F32H2.2b; -.
DR   PaxDb; P91869; -.
DR   EnsemblMetazoa; F32H2.2a.1; F32H2.2a.1; WBGene00007026. [P91869-2]
DR   EnsemblMetazoa; F32H2.2b.1; F32H2.2b.1; WBGene00007026. [P91869-1]
DR   GeneID; 185213; -.
DR   KEGG; cel:CELE_F32H2.2; -.
DR   UCSC; F32H2.2; c. elegans. [P91869-1]
DR   CTD; 185213; -.
DR   WormBase; F32H2.2a; CE47616; WBGene00007026; mdt-31.
DR   WormBase; F32H2.2b; CE47508; WBGene00007026; mdt-31.
DR   eggNOG; KOG4086; Eukaryota.
DR   GeneTree; ENSGT00390000015531; -.
DR   HOGENOM; CLU_071681_5_1_1; -.
DR   InParanoid; P91869; -.
DR   OMA; KRHRLCM; -.
DR   OrthoDB; 1480492at2759; -.
DR   PhylomeDB; P91869; -.
DR   PRO; PR:P91869; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00007026; Expressed in embryo and 4 other tissues.
DR   ExpressionAtlas; P91869; baseline and differential.
DR   GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.10.1340; -; 1.
DR   InterPro; IPR038089; Med31_sf.
DR   InterPro; IPR008831; Mediator_Med31.
DR   PANTHER; PTHR13186; PTHR13186; 1.
DR   Pfam; PF05669; Med31; 1.
PE   3: Inferred from homology;
KW   Activator; Alternative splicing; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..178
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   31"
FT                   /id="PRO_0000212529"
FT   REGION          129..178
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        130..156
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..13
FT                   /note="Missing (in isoform a)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_060782"
SQ   SEQUENCE   178 AA;  21332 MW;  4CB24A8FA779D306 CRC64;
     MGRFSFNRYG YNTMQMESVE SEKTRFEVEC EFVQALANPN YLNFLAQRGY FKEEYFVNYL
     KYLLYWKDPQ YARCLKFPQC LHMLEALQSQ QFRDSMAYGP SAKFVEDQVV LQWQFYLRKR
     HRLCMMPDEG QELEESEDEA DIRQKDTEDE DDEETMKKPD ADTAEKNSTT STVSKKEK