ID   MED31_DANRE             Reviewed;         136 AA.
AC   Q6DH26;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 2.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 31;
DE   AltName: Full=Mediator complex subunit 31;
DE   AltName: Full=Mediator complex subunit soh1;
GN   Name=med31; Synonyms=soh1;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 31 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH76157.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC076157; AAH76157.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001002417.2; NM_001002417.2.
DR   AlphaFoldDB; Q6DH26; -.
DR   SMR; Q6DH26; -.
DR   STRING; 7955.ENSDARP00000104686; -.
DR   PaxDb; Q6DH26; -.
DR   Ensembl; ENSDART00000124416; ENSDARP00000104686; ENSDARG00000008020.
DR   GeneID; 436690; -.
DR   KEGG; dre:436690; -.
DR   CTD; 51003; -.
DR   ZFIN; ZDB-GENE-040718-114; med31.
DR   eggNOG; KOG4086; Eukaryota.
DR   GeneTree; ENSGT00390000015531; -.
DR   HOGENOM; CLU_071681_5_1_1; -.
DR   InParanoid; Q6DH26; -.
DR   OMA; QILLWQH; -.
DR   OrthoDB; 1480492at2759; -.
DR   PhylomeDB; Q6DH26; -.
DR   TreeFam; TF105799; -.
DR   Reactome; R-DRE-212436; Generic Transcription Pathway.
DR   PRO; PR:Q6DH26; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 21.
DR   Bgee; ENSDARG00000008020; Expressed in testis and 29 other tissues.
DR   GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.10.1340; -; 1.
DR   InterPro; IPR038089; Med31_sf.
DR   InterPro; IPR008831; Mediator_Med31.
DR   PANTHER; PTHR13186; PTHR13186; 1.
DR   Pfam; PF05669; Med31; 1.
PE   2: Evidence at transcript level;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..136
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   31"
FT                   /id="PRO_0000305708"
FT   REGION          117..136
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   136 AA;  16521 MW;  38FBEF98D3BC3C2E CRC64;
     MAGVMETDEQ ARQRFQLELE FVQCLANPNY LNFLAQRGYL REKPFVNYLK YLLYWKEPEY
     AKFLKYPHCL HMLELLQYEH FRKELVNAQC AKFIDEQQIL HWQHYSRKRT RLQQALAEQQ
     QQQQPQAPSH ANTTSK