ID   MED31_DICDI             Reviewed;         176 AA.
AC   Q54NI7;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Putative mediator of RNA polymerase II transcription subunit 31;
DE   AltName: Full=Putative mediator complex subunit 31;
GN   Name=med31; ORFNames=DDB_G0285221;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 31 family.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000076; EAL64822.1; -; Genomic_DNA.
DR   RefSeq; XP_638330.1; XM_633238.1.
DR   AlphaFoldDB; Q54NI7; -.
DR   SMR; Q54NI7; -.
DR   STRING; 44689.DDB0266952; -.
DR   PaxDb; Q54NI7; -.
DR   EnsemblProtists; EAL64822; EAL64822; DDB_G0285221.
DR   GeneID; 8625000; -.
DR   KEGG; ddi:DDB_G0285221; -.
DR   dictyBase; DDB_G0285221; med31.
DR   eggNOG; KOG4086; Eukaryota.
DR   HOGENOM; CLU_071681_5_1_1; -.
DR   InParanoid; Q54NI7; -.
DR   OMA; ANPRYVH; -.
DR   PhylomeDB; Q54NI7; -.
DR   PRO; PR:Q54NI7; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR   GO; GO:0016592; C:mediator complex; ISS:dictyBase.
DR   GO; GO:0003713; F:transcription coactivator activity; ISS:dictyBase.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISS:dictyBase.
DR   Gene3D; 1.10.10.1340; -; 1.
DR   InterPro; IPR038089; Med31_sf.
DR   InterPro; IPR008831; Mediator_Med31.
DR   PANTHER; PTHR13186; PTHR13186; 1.
DR   Pfam; PF05669; Med31; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..176
FT                   /note="Putative mediator of RNA polymerase II transcription
FT                   subunit 31"
FT                   /id="PRO_0000388663"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..28
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   176 AA;  21437 MW;  EFE4049015801312 CRC64;
     MSSSSPINEN DNGNIENNNE TNITENGDNG ESIDKKDDNI VLPYENDEEE ANYLRFIMEL
     EFIQCLSNPR YLNYLAQNRY FQDKAFVNYL VYLQYWKKPE YAKFIVYPQS LYFLDLLQEE
     RFRQELNHSQ STDFIHEQQF YHWQYYRNNR MSIKEQELQQ QQQQQQQQQV QPPTTV