ID   MED31_ENCCU             Reviewed;         103 AA.
AC   Q8SU76;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 31;
DE   AltName: Full=Mediator complex subunit 31;
GN   Name=SOH1; Synonyms=MED31; OrderedLocusNames=ECU11_0360;
OS   Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC   Encephalitozoon.
OX   NCBI_TaxID=284813;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GB-M1;
RX   PubMed=11719806; DOI=10.1038/35106579;
RA   Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F.,
RA   Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P.,
RA   Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J.,
RA   Vivares C.P.;
RT   "Genome sequence and gene compaction of the eukaryote parasite
RT   Encephalitozoon cuniculi.";
RL   Nature 414:450-453(2001).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 31 family.
CC       {ECO:0000305}.
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DR   EMBL; AL590450; CAD25946.1; -; Genomic_DNA.
DR   RefSeq; NP_586342.1; NM_001042175.1.
DR   AlphaFoldDB; Q8SU76; -.
DR   SMR; Q8SU76; -.
DR   STRING; 284813.Q8SU76; -.
DR   GeneID; 859993; -.
DR   KEGG; ecu:ECU11_0360; -.
DR   VEuPathDB; MicrosporidiaDB:ECU11_0360; -.
DR   HOGENOM; CLU_071681_3_2_1; -.
DR   InParanoid; Q8SU76; -.
DR   OMA; LSNPWYL; -.
DR   OrthoDB; 1480492at2759; -.
DR   Proteomes; UP000000819; Chromosome XI.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   Gene3D; 1.10.10.1340; -; 1.
DR   InterPro; IPR038089; Med31_sf.
DR   InterPro; IPR008831; Mediator_Med31.
DR   PANTHER; PTHR13186; PTHR13186; 1.
DR   Pfam; PF05669; Med31; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..103
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   31"
FT                   /id="PRO_0000305725"
SQ   SEQUENCE   103 AA;  12743 MW;  324D5155C423EE55 CRC64;
     MSGSRFEREL EFVQLLCNPD YLRWLTREGH FESEEFRSYL RYLEYWRSPE YSRFLTYPQC
     LAVLEHLNSE NINDMLSDEN FFLALGEQQY FIWLNKHKEG WNK