MED31_XENTR
ID MED31_XENTR Reviewed; 128 AA.
AC Q28FE2; Q6GL95;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 02-OCT-2007, sequence version 2.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 31;
DE AltName: Full=Mediator complex subunit 31;
DE AltName: Full=Mediator complex subunit soh1;
GN Name=med31; Synonyms=soh1; ORFNames=TEgg024a05.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Egg;
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 31 family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH74608.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAJ81967.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CR762011; CAJ81967.1; ALT_INIT; mRNA.
DR EMBL; BC074608; AAH74608.1; ALT_INIT; mRNA.
DR RefSeq; NP_001004826.2; NM_001004826.2.
DR RefSeq; NP_001231694.1; NM_001244765.1.
DR AlphaFoldDB; Q28FE2; -.
DR SMR; Q28FE2; -.
DR STRING; 8364.ENSXETP00000037092; -.
DR PaxDb; Q28FE2; -.
DR DNASU; 448081; -.
DR Ensembl; ENSXETT00000038255; ENSXETP00000038255; ENSXETG00000017618.
DR GeneID; 448081; -.
DR KEGG; xtr:448081; -.
DR CTD; 51003; -.
DR Xenbase; XB-GENE-951034; med31.
DR eggNOG; KOG4086; Eukaryota.
DR HOGENOM; CLU_071681_5_1_1; -.
DR InParanoid; Q28FE2; -.
DR OMA; ANPRYVH; -.
DR OrthoDB; 1480492at2759; -.
DR Proteomes; UP000008143; Chromosome 2.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000017618; Expressed in egg cell and 14 other tissues.
DR GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.10.1340; -; 1.
DR InterPro; IPR038089; Med31_sf.
DR InterPro; IPR008831; Mediator_Med31.
DR PANTHER; PTHR13186; PTHR13186; 1.
DR Pfam; PF05669; Med31; 1.
PE 2: Evidence at transcript level;
KW Activator; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..128
FT /note="Mediator of RNA polymerase II transcription subunit
FT 31"
FT /id="PRO_0000305711"
FT CONFLICT 59
FT /note="E -> D (in Ref. 2; AAH74608)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 128 AA; 15697 MW; 66131140354F6701 CRC64;
MAAAMETDEQ QRIRFQLELE FVQCLANPNY LNFLAQRGYF KDKSFVNYLK YLLYWKDPEY
AKYLKYPQCL HMLELLQYEH FRKELVNAQC AKFIDEQQIL HWQHYSRKRM RMQQALAEQQ
QQNNTSGK
