ID   MED3_CANGA              Reviewed;         481 AA.
AC   Q6FXZ4;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 3;
DE   AltName: Full=Mediator complex subunit 3;
GN   Name=PGD1; Synonyms=MED3; OrderedLocusNames=CAGL0A01408g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       regulated gene transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 3 family.
CC       {ECO:0000305}.
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DR   EMBL; CR380947; CAG57721.1; -; Genomic_DNA.
DR   RefSeq; XP_444828.1; XM_444828.1.
DR   AlphaFoldDB; Q6FXZ4; -.
DR   SMR; Q6FXZ4; -.
DR   STRING; 5478.XP_444828.1; -.
DR   EnsemblFungi; CAG57721; CAG57721; CAGL0A01408g.
DR   GeneID; 2886469; -.
DR   KEGG; cgr:CAGL0A01408g; -.
DR   CGD; CAL0126757; CAGL0A01408g.
DR   VEuPathDB; FungiDB:CAGL0A01408g; -.
DR   eggNOG; ENOG502S3GT; Eukaryota.
DR   HOGENOM; CLU_049224_0_0_1; -.
DR   InParanoid; Q6FXZ4; -.
DR   OMA; FIQIMAN; -.
DR   Proteomes; UP000002428; Chromosome A.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR020998; Med3.
DR   Pfam; PF11593; Med3; 1.
PE   3: Inferred from homology;
KW   Activator; Coiled coil; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..481
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   3"
FT                   /id="PRO_0000302017"
FT   REGION          140..261
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          415..463
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          79..107
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        140..162
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        172..205
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        228..261
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   481 AA;  52084 MW;  9A14D6A77F790DC7 CRC64;
     MATKQEEQAN LSDVLTPSMS LTELEMKFAD ETDGKAKDVV QARIKKAEDG ILPLRLQFND
     FTQIMSSLDE ERYANVSKQE KFQMIRSKVL GLTERLQELS NDFEELQPLF ATVGEYSKTY
     KNKNFQVLEN LASYNHRGKA GASISNSTPT PAAATPTTAP TPGAGTKKAA KTAPTPTATA
     TIGTPSNNAP TPATTATTPG TQAKKPRKPR QTKKQQQAAA AAAAVAQAQA QAQAQAQNQN
     QNNMQNKNIS NPGMNSNMGT PVMGNPNMKQ MQSPIPANAM NNMNVPHNGA MRPSVPNGNM
     GNPSMGNLNM NAPNMGNPNM NNPNMNNPNA MMSPMAGQGQ LNQMFPMQNH NQNGQFMGQQ
     SPGPNIGQMQ FPPNNGNMNG MPGTSDMNLG MNPSMNMNMG MNLNQITPAN ILSMNTKGKD
     DQMQNIGMDQ NQNQNQSQNQ SQNQNQSMNM NMNNDSNNPK SAYDLVDFNS LDLSSLNMDF
     L