ID   MED4_CAEBR              Reviewed;         334 AA.
AC   Q621Z7; A8WUP6;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JAN-2010, sequence version 3.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 4;
DE   AltName: Full=Mediator complex subunit 4;
GN   Name=mdt-4; ORFNames=CBG02282;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 4 family.
CC       {ECO:0000305}.
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DR   EMBL; HE601438; CAP24208.2; -; Genomic_DNA.
DR   AlphaFoldDB; Q621Z7; -.
DR   SMR; Q621Z7; -.
DR   STRING; 6238.CBG02282; -.
DR   EnsemblMetazoa; CBG02282.1; CBG02282.1; WBGene00025360.
DR   WormBase; CBG02282; CBP37598; WBGene00025360; Cbr-mdt-4.
DR   eggNOG; KOG4552; Eukaryota.
DR   HOGENOM; CLU_832182_0_0_1; -.
DR   InParanoid; Q621Z7; -.
DR   OMA; TPNEKQW; -.
DR   OrthoDB; 1333917at2759; -.
DR   Proteomes; UP000008549; Chromosome II.
DR   GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR019258; Mediator_Med4.
DR   PANTHER; PTHR13208; PTHR13208; 1.
DR   Pfam; PF10018; Med4; 1.
PE   3: Inferred from homology;
KW   Activator; Coiled coil; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..334
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   4"
FT                   /id="PRO_0000390785"
FT   REGION          188..234
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          252..334
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          76..100
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        188..227
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        252..286
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        306..320
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   334 AA;  36470 MW;  218597ECDF4B13D3 CRC64;
     MTESDERSLR DLLLESADDL ENVLKMIIDT LINREKSVML KSGESVTNIV RLFDAKQESV
     RKLLQKVPEF QERESLIRTL KAHVEKRDEV IQQVENNLKA CEVALTRSCF HANQKVKKMN
     EAALRPVNSE TLIKLSHQIS KHNSVSAPLT WQIGDPSRPF PQEHEFRTGQ LLNPKIQSSG
     PQILLGKSSA QKPIIASPSA SSSNGGTAPT RTVGTPLVNS ATNGDYSPRT GYGAEETSPI
     QEQVLLGVTP NEKQWQNPPM PGAATSSQSP LSGAPQSPSS PSVKLKISGI PNRPGDIDQV
     QEVRDVEQMS SDSSNSSDSS DDEGSSKKTR GRNK