ID   MED4_CHAGB              Reviewed;         351 AA.
AC   Q2H2I4;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 4;
DE   AltName: Full=Mediator complex subunit 4;
GN   Name=MED4; ORFNames=CHGG_04012;
OS   Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS   NRRL 1970) (Soil fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=306901;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX   PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA   Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT   "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL   Genome Announc. 3:E0002115-E0002115(2015).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 4 family.
CC       {ECO:0000305}.
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DR   EMBL; CH408032; EAQ87393.1; -; Genomic_DNA.
DR   RefSeq; XP_001223226.1; XM_001223225.1.
DR   AlphaFoldDB; Q2H2I4; -.
DR   SMR; Q2H2I4; -.
DR   PRIDE; Q2H2I4; -.
DR   EnsemblFungi; EAQ87393; EAQ87393; CHGG_04012.
DR   GeneID; 4391553; -.
DR   eggNOG; ENOG502SCD7; Eukaryota.
DR   HOGENOM; CLU_057381_1_0_1; -.
DR   InParanoid; Q2H2I4; -.
DR   OMA; SKYNHQA; -.
DR   OrthoDB; 1436342at2759; -.
DR   Proteomes; UP000001056; Unassembled WGS sequence.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR019258; Mediator_Med4.
DR   Pfam; PF10018; Med4; 1.
PE   3: Inferred from homology;
KW   Activator; Coiled coil; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..351
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   4"
FT                   /id="PRO_0000302075"
FT   REGION          156..217
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          256..351
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          30..68
FT                   /evidence="ECO:0000255"
FT   COILED          262..311
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        156..195
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        258..328
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   351 AA;  39082 MW;  6E36AA9E4B358D3C CRC64;
     METNLDGCFE RVEKTLGSMI DSLAKNNPSQ KLAEELLAAE AELSKSLKLL ETHQNNNARL
     QQLRQETSLH DTQLKDIMSS LWNMRRELKA VPTTSNPPPG PKHQFTTSEL LAYARRISRN
     TLPLPGVTNG VDMTPTQFSA SLTEPEDSFR LQFQPTQTQT PTNSFNLSFN GTVSTPIGLS
     APTPTTTNDT QPSTQLPPSQ QPPPKTAPAD DKLPAHLKPA VNPLHDAAFH PWPTEGQIRT
     GALAALQRLV DAGIEPRGYD PAEQERRRVA EEKARREAEE RARLEREEAE RKGREERERM
     AREREAARLR NAGGADGDGE RRESVAVARP KPKQFTFLGA DDDEDDEDED D