ID   MED4_XENLA              Reviewed;         252 AA.
AC   Q5XG48;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 4;
DE   AltName: Full=Mediator complex subunit 4;
GN   Name=med4;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 4 family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC084617; AAH84617.1; -; mRNA.
DR   RefSeq; NP_001088367.1; NM_001094898.1.
DR   AlphaFoldDB; Q5XG48; -.
DR   SMR; Q5XG48; -.
DR   DNASU; 495214; -.
DR   GeneID; 495214; -.
DR   KEGG; xla:495214; -.
DR   CTD; 495214; -.
DR   Xenbase; XB-GENE-972357; med4.S.
DR   OrthoDB; 1333917at2759; -.
DR   Proteomes; UP000186698; Chromosome 2S.
DR   Bgee; 495214; Expressed in oocyte and 19 other tissues.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR019258; Mediator_Med4.
DR   PANTHER; PTHR13208; PTHR13208; 1.
DR   Pfam; PF10018; Med4; 1.
PE   2: Evidence at transcript level;
KW   Activator; Coiled coil; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..252
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   4"
FT                   /id="PRO_0000302066"
FT   REGION          213..252
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          5..31
FT                   /evidence="ECO:0000255"
FT   COILED          70..112
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   252 AA;  28056 MW;  153D93E42C280990 CRC64;
     MAVPKKSTKE RLESLLDDLE VLSREVIETL ALSRSQKLSQ PGEENQILEL LIQKDGEFQE
     LMKVAFSQGK THQEMQVLEK EVEKRDSDIQ QLQKQLKEAE HILATAVYQA KEKLKSIDKA
     RKGVISSEEL IKYAHRISAS NAVCAPLTWV PGDPRRPYPT DLEMRSGLLG QMSNLPTNGV
     NGHLPGDALA AGRLPDVLAP QYPWQSSDMS MNMLPPNHSN EFLMESLGPN KENEEDVEVM
     STDSSSSSSD SD