ID   MED4_XENTR              Reviewed;         252 AA.
AC   Q5M8Y7;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 4;
DE   AltName: Full=Mediator complex subunit 4;
GN   Name=med4;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 4 family.
CC       {ECO:0000305}.
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DR   EMBL; BC087778; AAH87778.1; -; mRNA.
DR   RefSeq; NP_001011218.1; NM_001011218.1.
DR   AlphaFoldDB; Q5M8Y7; -.
DR   SMR; Q5M8Y7; -.
DR   PaxDb; Q5M8Y7; -.
DR   DNASU; 496653; -.
DR   GeneID; 496653; -.
DR   KEGG; xtr:496653; -.
DR   CTD; 29079; -.
DR   Xenbase; XB-GENE-972352; med4.
DR   eggNOG; KOG4552; Eukaryota.
DR   HOGENOM; CLU_082233_1_0_1; -.
DR   InParanoid; Q5M8Y7; -.
DR   OrthoDB; 1333917at2759; -.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR019258; Mediator_Med4.
DR   PANTHER; PTHR13208; PTHR13208; 1.
DR   Pfam; PF10018; Med4; 1.
PE   2: Evidence at transcript level;
KW   Activator; Coiled coil; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..252
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   4"
FT                   /id="PRO_0000302067"
FT   REGION          218..252
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          70..112
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   252 AA;  28141 MW;  1BFBE6B5A1E7C1DA CRC64;
     MAVPEKSTKE RLMSFLDDLE VLSRELIEML ALSRNQKLSQ PGEENQILEL LIQKDGEFQE
     LMKVALSQGK IHQEMQVLEK EVEKRDSDIQ QLQKQLKEAE HILATAVYQA KEKLKSIDKA
     RKGAISSEEL IKYAHRISAS NAVCAPLTWV PGDPRRPYPT DLEMRSGLLG QMSNLPTNGV
     NGHLPGDALA AGRLPDVLAP QYPWQSNDMS MNMLPPNHSN EFLMESLGPN KENEEDVEVM
     STDSSSSSSD SD