ARHG3_CHICK
ID ARHG3_CHICK Reviewed; 524 AA.
AC Q5ZLX4;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Rho guanine nucleotide exchange factor 3;
GN Name=Arhgef3; ORFNames=RCJMB04_4i12;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Acts as guanine nucleotide exchange factor (GEF) for RhoA and
CC RhoB GTPases. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ719610; CAG31269.1; -; mRNA.
DR RefSeq; NP_001025766.1; NM_001030595.1.
DR AlphaFoldDB; Q5ZLX4; -.
DR SMR; Q5ZLX4; -.
DR STRING; 9031.ENSGALP00000008791; -.
DR PaxDb; Q5ZLX4; -.
DR PRIDE; Q5ZLX4; -.
DR GeneID; 416000; -.
DR KEGG; gga:416000; -.
DR CTD; 50650; -.
DR VEuPathDB; HostDB:geneid_416000; -.
DR eggNOG; KOG4305; Eukaryota.
DR InParanoid; Q5ZLX4; -.
DR PhylomeDB; Q5ZLX4; -.
DR PRO; PR:Q5ZLX4; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0035025; P:positive regulation of Rho protein signal transduction; IBA:GO_Central.
DR CDD; cd10572; PH_RhoGEF3_XPLN; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; -; 1.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR044129; PH_RhoGEF3_XPLN.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; SSF48065; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Guanine-nucleotide releasing factor; Reference proteome.
FT CHAIN 1..524
FT /note="Rho guanine nucleotide exchange factor 3"
FT /id="PRO_0000314288"
FT DOMAIN 121..303
FT /note="DH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00062"
FT DOMAIN 290..448
FT /note="PH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT REGION 75..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 524 AA; 59998 MW; D21292EE87D17A9D CRC64;
MVAKDYPFYL TVKRANCALD VEAASSPAKE TEEPSNKRVK PLSRVTSLAN LIPPVRATPL
KRFSQTLQRS ISFRSDSRPD LFSPRPWSRN TPAANTKRRD SKLWSETFDV CVNHMLTSKE
IKRQEAIFEL SKGEEDLIED LKLAKKAYHD PMLKLSIMTE QELNQIFGTL DSLIPLHEDL
LRRLQEVRKS DGSTEHVGHI LVGWLPCLNS YDSYCSNQVA AKALLDHKKQ DHRVQDFLQR
CLESPFSRKL DLWNFLDIPR SRLVKYPLLL REILRHTPND HPDQQHLEEA INIIQGIVAE
INIKTGESEC QYYKERLIYL EGGQRDSLID NSRVLCCHGE LKNNRGVKLH VFLFQEVLVI
TRAITHNEQL CYQLYRQPIP VMDLVLEDLQ DGEVRLGGSI RGAFSNNERI KNFFRVSFKN
GSQSQSHSLQ ANDSFNKQQW LNCIRQAKEK VTCAGKAGVL SSEACFILSP NGSRVSQGET
MIEQMDQSDS ESDCSMDTSE ISIDCERMEQ TNPCENEKQI ETNV
