ID   MED5_ASPCL              Reviewed;        1020 AA.
AC   A1CGW7;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 2.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 5;
DE   AltName: Full=Mediator complex subunit 5;
GN   Name=nut1; Synonyms=med5; ORFNames=ACLA_045870;
OS   Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS   NRRL 1 / QM 1276 / 107).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=344612;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 5 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAW10122.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; DS027054; EAW10122.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_001271548.1; XM_001271547.1.
DR   AlphaFoldDB; A1CGW7; -.
DR   STRING; 5057.CADACLAP00004739; -.
DR   EnsemblFungi; EAW10122; EAW10122; ACLA_045870.
DR   GeneID; 4704159; -.
DR   KEGG; act:ACLA_045870; -.
DR   eggNOG; ENOG502R1HB; Eukaryota.
DR   OrthoDB; 1352388at2759; -.
DR   Proteomes; UP000006701; Unassembled WGS sequence.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR014801; Mediator_Med5_fun.
DR   PANTHER; PTHR35784; PTHR35784; 1.
DR   Pfam; PF08689; Med5; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..1020
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   5"
FT                   /id="PRO_0000302767"
SQ   SEQUENCE   1020 AA;  111721 MW;  0F133CA6C448A3C7 CRC64;
     MTAPGQWGTF LHQCLMHRID ATEFKSLLKL MFQKCPITET ALLDALLQTR LKSRIKWDPL
     LPLYIDCLCR MGRVRTSTVL TSLLKYSSIH EDSQPLVPAA KEGSKGYTLM TDIRVIQDAM
     LSVSTGGTPK TIAEAIAIFF SIIDWIHAVV AWHHSHLDHS QHPGGLMSSP DVVSVFESLG
     ILLAALSGTG KGLEVLSADS HEELKVKLGQ ALSAYLPLCV EVSLPLRNRL DGLQKEFHLY
     GEPSSKSLNV PMMDNVNVNA LQFEASVMDG PVIHSRAGLY VYINAMLVGR PLVDDSMLIN
     FLANRYGGHY EVLIEEIITA AFDVLSNAMY RNESSRTMFL FRSFLVNKLP PFFAAMLAST
     MVSIPMEMCI SQALGRLDPN TFPSFSQMFE MQGNTVLSDV RQEFLFACAS HKLIPESSIE
     RMLGENPMQA LPVGYNKDEL VSQINTNPER AEQLINEIES MEGNAGAIVG AITEIMHNLC
     NQKETVTLKN ICNSLSRRPQ ALDVILLFRS AKQVLQPLCG LLDSWHWDED QGENQPVYDE
     FGSILLLVLA FKYRFDLRPA DLGISSNDSF VLKLLERGSC SQKLDALDEK QNKNLGTWIA
     ALFIAEGISE ETMSACSPQE FYLLVATLFS QSLGACETGK LEFDTLKGGF EYLLEPFLLP
     SLVFALTWLG NHIWETEPEP SIALKALHSL VNPSSISGEG REIHRTVLHT VARMLEEQLK
     DVRTRHPSRT DIKPIMDSLE PCLSFQRVGS CHRSELEGWT THAGGGLLGS IRSTFQALVL
     WSANPEVSMA PPSYTHRQVV AGIRMLGAAR VFGALVDELV KLQTQTQTQT QAGSSDLALD
     LAATLVCAPL SEAFAVEQNS HHPVDPSKEA LPRCAVLTLR DALALQHENV PKLAEKDPLR
     AEVVVRLARR VAALLAPPSQ VPNLDVNNII QNMQLGIEGS GPMELDGPGP AADDDDDAEN
     IHRMIDNAAA AAAAAGMDSG VGVGVGQGTG LDTSIDDVLN AADMAVGNPE FLDLDMEGMF