ID   MED5_ASPFU              Reviewed;        1007 AA.
AC   Q4WNQ6;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 2.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 5;
DE   AltName: Full=Mediator complex subunit 5;
GN   Name=nut1; Synonyms=med5; ORFNames=AFUA_4G06600;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 5 family.
CC       {ECO:0000305}.
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DR   EMBL; AAHF01000005; EAL90128.2; -; Genomic_DNA.
DR   RefSeq; XP_752166.2; XM_747073.2.
DR   AlphaFoldDB; Q4WNQ6; -.
DR   STRING; 746128.CADAFUBP00006194; -.
DR   EnsemblFungi; EAL90128; EAL90128; AFUA_4G06600.
DR   GeneID; 3509258; -.
DR   KEGG; afm:AFUA_4G06600; -.
DR   VEuPathDB; FungiDB:Afu4g06600; -.
DR   eggNOG; ENOG502R1HB; Eukaryota.
DR   HOGENOM; CLU_004096_0_0_1; -.
DR   InParanoid; Q4WNQ6; -.
DR   OMA; CNQKETM; -.
DR   OrthoDB; 1352388at2759; -.
DR   Proteomes; UP000002530; Chromosome 4.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR014801; Mediator_Med5_fun.
DR   PANTHER; PTHR35784; PTHR35784; 1.
DR   Pfam; PF08689; Med5; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..1007
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   5"
FT                   /id="PRO_0000302768"
SQ   SEQUENCE   1007 AA;  110958 MW;  E235D657D56012D4 CRC64;
     MTSPVQWGTF FHQCLLHRID ANEFRNLSKL LLQKCPIAET ALLDALLQTR SESRIKWDPL
     LPLYIDCLCR TGRVRTSTVL TSLLKYSSIH DKPQLSTSEG KDGSKCYTLM TDIRVIQDTM
     LSVSTGSTPK TNAEAVAIFF AIIDWIHAVA SWHNSHFDPG QHSSGIMSSP DVVSLFESLG
     ILLAALSGTG KGLEVLSADS HEGLKVKLGQ ALSAYLPLCV EVSLPLRNRL DGLQKEFNLY
     GERVPKSLDV PMMENMNVNA LQFEASVMDG PVINSRAGLY VFINAMLVGR PLVDDGMLIN
     YLANRYGGHY EALVEEILTA SFDVLSNGMY RNESSRMMFV FRSFLVNKLP PFFAAMLAST
     MVSIPMEMCI SHALSRLDPN TFPSFSQMFE MQGNTVLSDV RQEFLFACAS HKLIPESSIE
     RLLGENPMQT LPVGYNKDEL VSQINANPER AEQLINEIES MEGNAGAIIG AITEVMHNLC
     NQKETMTLKN ICNSLSRRPQ ALDVVLIFRN PKQVLQPLCA LLDSWHWDED QGEYQPVYDE
     FGSILLLVLA FKYRFDLRPA DLGISSSDSF VLRLLERGSC SQKLDALDEK QNKNLGSWIA
     ALFIAEGISE ETMSACSPQE FYLLVATLFS QSLEACETGK LEFDTLKGGF EYLLEPFLLP
     SLIFALTWLG DHIWEMELDP SIPLKVLHSL VNPSSISGEA REIHRTVLNI AARTLEEQLK
     DVRTRHPSRT DIKPILDSLE PCLSFQLVGS SHRSELEGWT THSSGGLLGS IRSTFQSLVL
     WSTNPEVSMA PPPYTHRQLI AGVRMLGASR VLPALIEELK LQTEAGNGPL ALDLAATLIC
     APMAETFSVE QNSHQPVDPN KEALPRCGIL TLRDVLALQH ENVPKISEKD PLRAEVLVRL
     YRRVNALLAP PSQVPNLDVN NIIQNMQLGG VGVGAGQMEL DATGAADHGV GPDDAENIHR
     MIDNAAAAAG LDSSGTGLDT SIDDVLNAAD MAVGNPEFLD LDMEGMF