ID   MED5_ASPOR              Reviewed;        1013 AA.
AC   Q2UG94;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 2.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 5;
DE   AltName: Full=Mediator complex subunit 5;
GN   Name=NUT1; Synonyms=MED5; ORFNames=AO090023000929;
OS   Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=510516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42149 / RIB 40;
RX   PubMed=16372010; DOI=10.1038/nature04300;
RA   Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA   Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA   Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA   Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA   Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA   Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA   Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA   Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA   Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA   Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA   Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA   Kikuchi H.;
RT   "Genome sequencing and analysis of Aspergillus oryzae.";
RL   Nature 438:1157-1161(2005).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 5 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAE59421.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AP007157; BAE59421.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001821423.2; XM_001821371.2.
DR   AlphaFoldDB; Q2UG94; -.
DR   STRING; 510516.Q2UG94; -.
DR   VEuPathDB; FungiDB:AO090023000929; -.
DR   Proteomes; UP000006564; Chromosome 3.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR014801; Mediator_Med5_fun.
DR   PANTHER; PTHR35784; PTHR35784; 1.
DR   Pfam; PF08689; Med5; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..1013
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   5"
FT                   /id="PRO_0000302769"
SQ   SEQUENCE   1013 AA;  111424 MW;  7A4A2CE0F19BC284 CRC64;
     MTSSEQWRAF LHQCLMRRID AAEFKNLSKI LFRRCPTAEG TLLDVLLEIR LATGIKWDPL
     LPLYIDCLCK MGKVQTSTVL TSLLKYSSIH DKPQSPSSET VQSKMALKCY TLMTDIRVIQ
     DAMLSVSTGS TPKSLAEAVG IFSAIIDWIQ AVVAWHNNHI DPSQQTGGLM SSPDAVSLFE
     SLGILLTALS GTGKGIEVLS SDSHEALKVK LGQALSAYLP LCMEVSLPLR NRLDSLQKGF
     NLYGEPPNKS LQSMMDNVNV NALQFEASVM DGPVINSRAG LYIYINAMLV GRPLVDDSML
     LNYLTNRYGG HYDVLVEEVI TATFDVLSNA LYRNESSRTM FLFRSFLVNK LPSFFAAMLA
     ASMVSLPMEM CISHALSRLD PNTFPSFSQM FAMQGSTVLS EVRPEFLFAC ASHKLIPESS
     IERLLGENPM QTPPVGYNKD DLVSQINTNQ ERAEQLVSEL ESTEGNAGAI VAAITEVMHN
     LCNQKETMTL KSICNSLSRR PQALDVILLF RSAKQVLQPL CALLDSWHWD EDQGESQPVY
     DEFGSILLLV LTFKYRYDLR PYDLGITSND SFVLKLLDCG SSSQNLDDLS EKQNRNLGAW
     ITALFIAEGI SEETMSSCSP QEFYLLVTTL FNQSLTACEA GKLEFDTLKG GFEYLLEPFL
     LPSLVVALTW LGNHIWETES DPTIPLKTLQ SLVNPSSISG DAREIHKTVL NITARSLDEQ
     LKDIRSRHPN RADIKPILDV LEPCLSFQRT GSCHRSELDS WTTHSPGGLL GSIRSTFQGL
     VLWSTSPGVS MAPHSYTHRQ LVAGIRMLGS ARVLTAIVDE LKMQTETGNA DLALDIAVTM
     ICAPLAESFA IEQSNYHPVD PNKEPLPRCP VLTLRDALNL QHENVPKLSE KDPLRAEVIV
     RLYRRVNALM TPTSQMPNLD MSNIIQDMQL GVEDHGQMDL EPAGAGHGVG DDDAANLNRM
     LDNAAAAAAA GLDSGMGQGM GGGLDTSIDD VLNAADMAVG NPEFLDLDME GMF