ID   MED5_ASPTN              Reviewed;        1016 AA.
AC   Q0CL68;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 2.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 5;
DE   AltName: Full=Mediator complex subunit 5;
GN   Name=nut1; Synonyms=med5; ORFNames=ATEG_05566;
OS   Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=341663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIH 2624 / FGSC A1156;
RA   Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA   Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA   Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA   Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA   Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA   Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA   Nierman W.C., Milne T., Madden K.;
RT   "Annotation of the Aspergillus terreus NIH2624 genome.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 5 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAU34635.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CH476600; EAU34635.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001214744.1; XM_001214744.1.
DR   AlphaFoldDB; Q0CL68; -.
DR   STRING; 341663.Q0CL68; -.
DR   GeneID; 4320977; -.
DR   eggNOG; ENOG502R1HB; Eukaryota.
DR   OrthoDB; 1352388at2759; -.
DR   Proteomes; UP000007963; Unassembled WGS sequence.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR014801; Mediator_Med5_fun.
DR   PANTHER; PTHR35784; PTHR35784; 1.
DR   Pfam; PF08689; Med5; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..1016
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   5"
FT                   /id="PRO_0000302770"
SQ   SEQUENCE   1016 AA;  110458 MW;  485D11F3C77EA3E5 CRC64;
     MASTEQWGAF LHQCLAHRID VADFKNLSRL LFKRNPIAQG ALIDVVLETR LAAGIKWDPL
     LPLYIDGLCK MGKLQISTVL AALLKHSSIH EKPGTDAAAA KQKQKCYTLM TDIRVIQDAM
     LAVSTGHAPK SLSETAGTFL AIADWIHAVV SWHHGQMNAS QQAEGLMSSP DAVSLFESLG
     ILLAAVSGTE KGLQVLSSDS NEGLKVKLGH ALSAYLPLCV DLSLPLRNRL DALQKEFNLY
     GEPPPKNLGV SSLENLHVNG IQFEASIIDG PAINSRAGLY VYINAMLAGR PLVDDSMLLN
     YLTNRYGAHY DVLIQDLITA AFDVCSNAMY RNESSRTMFL FRSFLVNKLP SFFAAMLSAS
     MVSIPMELCI SHALSRLDPN TFPSFSQMFS MQGNTVLSDV RQEFLFACAS HKLIPESSIE
     RLLGENPMQA LPVGYNKDDL VSQINTTPER AEQLINEIEF TEGNAGPIVG AITEVMQNLC
     NQKETMTLKN ICNSLSRRPQ ALDVILLFRS PKQVLQPLCA LLDSWHWDED QGESQPVYDE
     FGSILLLVLV FKYRYDLSAY DLGIANNDSF VLRLLERGSS SQKLDELSES QNKHLGSWIG
     ALFIAEGISE ETMSACSPQE FYLLASTLFS QSLAACEAGK LEFETLKGGF EYLLEPFLLP
     SLVVALTWLG NHIWEAESDP SIPLKALHSL VSPSSISGEA KEIHRTVLNI TARSLDEQLK
     DVRARHPSRT DIKPILDVLE PCLSFPRTGS CHRSELETWT THAGNLLGSI RSTMQSLVLW
     CTSPDVNIPP PSYTHRQLVA GIRIVGATRL LAALLDELRL QTDANNGDLA LDIAASLVCA
     PLPESFAVES SPYHPVAVDL AKDPVPRCPL LTLRDALALQ HEAVPRTAEK DPARAEAVVR
     LYRRVAALAA PTAQVPNLDM NNLIQNMQLG VGVDGHDQMG LPAGGAGDAV GDEPNLDQML
     DNAAAAAAAG IDSGVGQGMG GDMSGGLDTS IDDVLNAADM AVGNPEFLDL DMEGMF