ID   MED5_PHANO              Reviewed;         984 AA.
AC   Q0USP2; Q0USP1;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 3.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 5;
DE   AltName: Full=Mediator complex subunit 5;
GN   Name=NUT1; Synonyms=MED5; ORFNames=SNOG_05221, SNOG_05222, SNOG_05223;
OS   Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume
OS   blotch fungus) (Parastagonospora nodorum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Pleosporomycetidae; Pleosporales; Pleosporineae; Phaeosphaeriaceae;
OC   Parastagonospora.
OX   NCBI_TaxID=321614;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SN15 / ATCC MYA-4574 / FGSC 10173;
RX   PubMed=18024570; DOI=10.1105/tpc.107.052829;
RA   Hane J.K., Lowe R.G.T., Solomon P.S., Tan K.-C., Schoch C.L.,
RA   Spatafora J.W., Crous P.W., Kodira C.D., Birren B.W., Galagan J.E.,
RA   Torriani S.F.F., McDonald B.A., Oliver R.P.;
RT   "Dothideomycete-plant interactions illuminated by genome sequencing and EST
RT   analysis of the wheat pathogen Stagonospora nodorum.";
RL   Plant Cell 19:3347-3368(2007).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 5 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAT87614.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CH445331; EAT87614.2; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001795631.1; XM_001795579.1.
DR   AlphaFoldDB; Q0USP2; -.
DR   STRING; 13684.SNOT_05223; -.
DR   PRIDE; Q0USP2; -.
DR   GeneID; 5972506; -.
DR   KEGG; pno:SNOG_05223; -.
DR   eggNOG; KOG0725; Eukaryota.
DR   InParanoid; Q0USP2; -.
DR   OrthoDB; 1352388at2759; -.
DR   Proteomes; UP000001055; Unassembled WGS sequence.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR014801; Mediator_Med5_fun.
DR   PANTHER; PTHR35784; PTHR35784; 1.
DR   Pfam; PF08689; Med5; 2.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..984
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   5"
FT                   /id="PRO_0000302783"
SQ   SEQUENCE   984 AA;  107931 MW;  3762D7D70BEEFCC2 CRC64;
     MCVPAKQGTL HAKSPLPGLK IAGLLLRPRA ANASSVDPRV IIYLERLLAL KKVDASDVLS
     SAFQYSKDRL PKTGDDGSSK DSGWHNPPEL EEVVFHRLSK AFQAEERPVN STEGLRTLVV
     VTRWMQTMVT SHTSDTMIQA MAGIQQQPQQ QSINVREGLG MLVVGVIENQ KMLNILNKHH
     IKNCKSPGRS RKSNTTFTTN LATGEWRSER RSRTETQDLK SLRSNFEAVD WIFPTINTRA
     GLYIFLNSLI DSQNMATDLI TAAFDILANA MYRSEPSQNM FCLKSFLINK IPILLLQISS
     SMFPMTAELS ITQALSHVDP NAFPAFSQGF DDMLGNTNSL ADVRQDFLNA CALHGLITTA
     TVERLLGETP MQGPPGTKYD KSTLLEQCKS NFDKISMYID ELDNLDGNAG AIVGAIAEFI
     PHLCETQMTM YLKQLSSLLF KKPQAIDVIL QFTSPASILR PLCQILDDWH YDSDQGEYQP
     VYDEFGAVLV LVMTFMYRYD LTYHDIGIGA ESFVARLMTK GNQSMLPDEM TDEQSKHLGH
     WLKGLYDAGN EGLSNDVFAS CSPREFYFIV PTLFKQTVMA LSAGILTFES VKGGLEYLME
     TFLLPSLIGG LIWMSSYALI QSHSDLDAIM RIFREVISSA PSSGDAQAMH STILSIVSSR
     LEKCLRTIQR RDASRANSIE PLIQAIKGNL HSERSMFASM KELEQWTNAP NSTLHTSLRH
     TVQQLSQWAS TSSIQPNPPS YTHRQVYVSL KIMGASKVIK AIVDELKAQT EASNGAAALD
     VGVSIICAPT VDDSPVPVAW LSSPIPASNP PRTRLNLREM LKHEFDNAAA LVATDPLAAE
     TVVRLHRRVE AQLSSIAENA LQGHGSVLNL PNVNMGDMQS QSIPDDITKA IDDAAAASIA
     DDITTMDNKA LQRSMDDLTG PDGLDLSSIG MGTGDAGTGD MGAELGNLPD LDLGDMSGMG
     MDMDMDMAMG GGGDDDWGLD FDNM