ID   MED6_ASPFU              Reviewed;         324 AA.
AC   Q4WDH9;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 6;
DE   AltName: Full=Mediator complex subunit 6;
GN   Name=med6; ORFNames=AFUA_6G04810;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 6 family.
CC       {ECO:0000305}.
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DR   EMBL; AAHF01000012; EAL85559.1; -; Genomic_DNA.
DR   RefSeq; XP_747597.1; XM_742504.1.
DR   AlphaFoldDB; Q4WDH9; -.
DR   SMR; Q4WDH9; -.
DR   STRING; 746128.CADAFUBP00009085; -.
DR   EnsemblFungi; EAL85559; EAL85559; AFUA_6G04810.
DR   GeneID; 3505209; -.
DR   KEGG; afm:AFUA_6G04810; -.
DR   VEuPathDB; FungiDB:Afu6g04810; -.
DR   eggNOG; KOG3169; Eukaryota.
DR   HOGENOM; CLU_060172_2_0_1; -.
DR   InParanoid; Q4WDH9; -.
DR   OMA; FIVGEEP; -.
DR   OrthoDB; 1251252at2759; -.
DR   Proteomes; UP000002530; Chromosome 6.
DR   GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 3.10.450.580; -; 1.
DR   InterPro; IPR007018; Mediator_Med6.
DR   InterPro; IPR016612; Mediator_Med6_fun.
DR   InterPro; IPR038566; Mediator_Med6_sf.
DR   PANTHER; PTHR13104; PTHR13104; 1.
DR   Pfam; PF04934; Med6; 1.
DR   PIRSF; PIRSF013286; MED6_fungi; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..324
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   6"
FT                   /id="PRO_0000303049"
FT   REGION          178..230
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          271..324
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        271..285
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   324 AA;  35128 MW;  0DA7A75B7D43DD16 CRC64;
     MAGPQDASLE EILWRSPPHV QMMGGYLHSN NILFYFAESP FFDATSNNAS LAIQANYNEA
     FRHFVETREA FEGRLRTMQG LEFVVAYDPL QAAAQTDTQF AHEPSNVWVI RKQMRRKRAG
     QEDEVVVLAT FFVVGDCIYM APSVASVVGN RILSAVTSLT SLLKTASTLP IFTPAHGHTY
     LPPAPKPADA GQPGVPSQQS KENTPMPDAE NPARVPLVGS QAGNTASTFQ DTRTLAESLH
     LFLRYEDEYM DENPLVGEPG SFIMSKANDV DRTATAKQPQ STIPTKMGAP LVRVDTPGKG
     PEKVGTPSSS DESSLKKKKG GVGG