ID   MED6_ASPTN              Reviewed;         324 AA.
AC   Q0CH76;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 2.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 6;
DE   AltName: Full=Mediator complex subunit 6;
GN   Name=med6; ORFNames=ATEG_06966;
OS   Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=341663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIH 2624 / FGSC A1156;
RA   Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA   Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA   Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA   Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA   Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA   Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA   Nierman W.C., Milne T., Madden K.;
RT   "Annotation of the Aspergillus terreus NIH2624 genome.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 6 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAU32350.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CH476603; EAU32350.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001209652.1; XM_001209652.1.
DR   AlphaFoldDB; Q0CH76; -.
DR   STRING; 341663.Q0CH76; -.
DR   EnsemblFungi; EAU32350; EAU32350; ATEG_06966.
DR   GeneID; 4319125; -.
DR   eggNOG; KOG1224; Eukaryota.
DR   eggNOG; KOG3169; Eukaryota.
DR   OrthoDB; 174949at2759; -.
DR   Proteomes; UP000007963; Unassembled WGS sequence.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   Gene3D; 3.10.450.580; -; 1.
DR   InterPro; IPR007018; Mediator_Med6.
DR   InterPro; IPR016612; Mediator_Med6_fun.
DR   InterPro; IPR038566; Mediator_Med6_sf.
DR   PANTHER; PTHR13104; PTHR13104; 1.
DR   Pfam; PF04934; Med6; 1.
DR   PIRSF; PIRSF013286; MED6_fungi; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..324
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   6"
FT                   /id="PRO_0000303052"
FT   REGION          172..217
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          254..324
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        183..217
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        264..278
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        307..324
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   324 AA;  35034 MW;  956C25596CFD782B CRC64;
     MAGTQDAPLE EILWRSPSHV QMMGGFLHSN NILFYFAESP FFDATSNNAS LAIQANYNET
     FRHFVETREA FEGRLKTMQG LEFVVSYDPL QAAAQSNGQF AHEPSNIWVI HKQTRRKRPG
     LEDEVEVLST FFVVGDCIYM APSVASVVGN RILSAVTSLT NLMKTAASLP NFTPAHGHTY
     MPPVSKSTDT AQPSAQPSKE NTPMPDADST KASLVGGAQS TNAGSVFQHT RTLAESFSLL
     TQYGDEFMDE NPLVGEPGSF IMSRNNEGAA SKQPPVGTTR PGTVPVRAGT PQVKVDTPGK
     TPDKGLTPGP DENKLRKKKG KSGV