MED6_BOVIN
ID MED6_BOVIN Reviewed; 246 AA.
AC Q3SZY9;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 6;
DE AltName: Full=Mediator complex subunit 6;
GN Name=MED6;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the Mediator complex, which is composed of MED1,
CC MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L,
CC MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23,
CC MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and
CC CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
CC module termed the CDK8 module. Mediator containing the CDK8 module is
CC less active than Mediator lacking this module in supporting
CC transcriptional activation. Individual preparations of the Mediator
CC complex lacking one or more distinct subunits have been variously
CC termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with CTNNB1 and
CC GLI3 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 6 family.
CC {ECO:0000305}.
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DR EMBL; BC102648; AAI02649.1; -; mRNA.
DR RefSeq; NP_001029409.1; NM_001034237.2.
DR AlphaFoldDB; Q3SZY9; -.
DR SMR; Q3SZY9; -.
DR STRING; 9913.ENSBTAP00000008922; -.
DR PaxDb; Q3SZY9; -.
DR PRIDE; Q3SZY9; -.
DR Ensembl; ENSBTAT00000008922; ENSBTAP00000008922; ENSBTAG00000006786.
DR GeneID; 505293; -.
DR KEGG; bta:505293; -.
DR CTD; 10001; -.
DR VEuPathDB; HostDB:ENSBTAG00000006786; -.
DR VGNC; VGNC:31369; MED6.
DR eggNOG; KOG3169; Eukaryota.
DR GeneTree; ENSGT00390000017666; -.
DR HOGENOM; CLU_077754_1_0_1; -.
DR InParanoid; Q3SZY9; -.
DR OMA; HLHNMIG; -.
DR OrthoDB; 1251252at2759; -.
DR TreeFam; TF313577; -.
DR Proteomes; UP000009136; Chromosome 10.
DR Bgee; ENSBTAG00000006786; Expressed in oocyte and 105 other tissues.
DR ExpressionAtlas; Q3SZY9; baseline.
DR GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 3.10.450.580; -; 1.
DR InterPro; IPR007018; Mediator_Med6.
DR InterPro; IPR016820; Mediator_Med6_met/pln.
DR InterPro; IPR038566; Mediator_Med6_sf.
DR PANTHER; PTHR13104; PTHR13104; 1.
DR Pfam; PF04934; Med6; 1.
DR PIRSF; PIRSF023869; Mediator_MED6_meta/pln; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Activator; Isopeptide bond; Nucleus; Reference proteome;
KW Transcription; Transcription regulation; Ubl conjugation.
FT CHAIN 1..246
FT /note="Mediator of RNA polymerase II transcription subunit
FT 6"
FT /id="PRO_0000283797"
FT REGION 191..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..226
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 236
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:O75586"
FT MOD_RES 241
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:O75586"
FT CROSSLNK 208
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:O75586"
SQ SEQUENCE 246 AA; 28406 MW; 14E3E52F25377575 CRC64;
MAAVDIRDNL LGISWVDSSW IPILNSGSVL DYFSERSNPF YDRTCNNEVV KMQRLTLEHL
NQMVGVEYIL LHAQEPILFI IRKQQRQSPT QVIPLADYYI IAGVIYQAPD LGSVINSRVL
TAVHGIQSAF DEAMSYCRYH PSKGYWWHFK DHEEQDKVKP KVKRKEEPSS IFQRQRVDAL
LLDLRQKFPP KFVQQKSGEK PVPVDQTKKE AEPLPETVKS EEKETAKNVQ QTVGTKGPPE
KRMRLQ