ID   MED6_CAEBR              Reviewed;         246 AA.
AC   Q60WM1; A8XUQ2;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 6;
DE   AltName: Full=Mediator complex subunit 6;
GN   Name=mdt-6; ORFNames=CBG19070;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. Interacts with let-19/mdt-
CC       13. Interacts with RNA polymerase II. Interacts with mdt-28.
CC       {ECO:0000250|UniProtKB:O75586, ECO:0000250|UniProtKB:Q9N337}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 6 family.
CC       {ECO:0000305}.
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DR   EMBL; HE601047; CAP36377.1; -; Genomic_DNA.
DR   RefSeq; XP_002637369.1; XM_002637323.1.
DR   AlphaFoldDB; Q60WM1; -.
DR   SMR; Q60WM1; -.
DR   STRING; 6238.CBG19070; -.
DR   GeneID; 8579364; -.
DR   KEGG; cbr:CBG_19070; -.
DR   CTD; 8579364; -.
DR   WormBase; CBG19070; CBP43242; WBGene00038348; Cbr-mdt-6.
DR   eggNOG; KOG3169; Eukaryota.
DR   HOGENOM; CLU_077754_1_1_1; -.
DR   InParanoid; Q60WM1; -.
DR   OMA; FYEMNSC; -.
DR   OrthoDB; 1251252at2759; -.
DR   Proteomes; UP000008549; Chromosome V.
DR   GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 3.10.450.580; -; 1.
DR   InterPro; IPR007018; Mediator_Med6.
DR   InterPro; IPR016820; Mediator_Med6_met/pln.
DR   InterPro; IPR038566; Mediator_Med6_sf.
DR   PANTHER; PTHR13104; PTHR13104; 1.
DR   Pfam; PF04934; Med6; 1.
DR   PIRSF; PIRSF023869; Mediator_MED6_meta/pln; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..246
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   6"
FT                   /id="PRO_0000303046"
FT   REGION          165..186
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          207..246
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        207..223
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   246 AA;  28611 MW;  8203E483270F56E9 CRC64;
     MMPRMGPPSS SKQEPTMFMS FRNPQWPANF INRDNVLDYF CNQGNVFYEM NSCNQQIKMQ
     NITNRSVDEC LRNMQGIQYV LWYSQPPLYI VCKQRRNNAT NVSPIAYYYV INGSVHQAPD
     MHTLVQSRLL GALEPLRNAF GEVTNYSRYN TAKGYYWEFK NKPSMKKKEE EKKEEDERKL
     EERSTNFQKA RTMMLLNQLF TEMPADEALE KLDVKEEENP KPEEAPSASA VGEPKFAEPA
     ARATTK