ID   MED6_CANGA              Reviewed;         302 AA.
AC   Q6FW12;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 6;
DE   AltName: Full=Mediator complex subunit 6;
GN   Name=MED6; OrderedLocusNames=CAGL0D03828g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 6 family.
CC       {ECO:0000305}.
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DR   EMBL; CR380950; CAG58493.1; -; Genomic_DNA.
DR   RefSeq; XP_445582.1; XM_445582.1.
DR   AlphaFoldDB; Q6FW12; -.
DR   STRING; 5478.XP_445582.1; -.
DR   EnsemblFungi; CAG58493; CAG58493; CAGL0D03828g.
DR   GeneID; 2887259; -.
DR   KEGG; cgr:CAGL0D03828g; -.
DR   CGD; CAL0128473; CAGL0D03828g.
DR   VEuPathDB; FungiDB:CAGL0D03828g; -.
DR   eggNOG; KOG3169; Eukaryota.
DR   HOGENOM; CLU_077754_0_0_1; -.
DR   InParanoid; Q6FW12; -.
DR   OMA; MQRQFSQ; -.
DR   Proteomes; UP000002428; Chromosome D.
DR   GO; GO:0070847; C:core mediator complex; IEA:EnsemblFungi.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003713; F:transcription coactivator activity; IEA:EnsemblFungi.
DR   GO; GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR   GO; GO:0060261; P:positive regulation of transcription initiation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR   GO; GO:0051123; P:RNA polymerase II preinitiation complex assembly; IEA:EnsemblFungi.
DR   Gene3D; 3.10.450.580; -; 1.
DR   InterPro; IPR007018; Mediator_Med6.
DR   InterPro; IPR016612; Mediator_Med6_fun.
DR   InterPro; IPR038566; Mediator_Med6_sf.
DR   PANTHER; PTHR13104; PTHR13104; 1.
DR   Pfam; PF04934; Med6; 1.
DR   PIRSF; PIRSF013286; MED6_fungi; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..302
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   6"
FT                   /id="PRO_0000303054"
FT   REGION          260..281
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   302 AA;  33218 MW;  2CA20D10625EEDE3 CRC64;
     MDTPLDELQW KSPEWIQAFG LRTDNVLDYF AESPFFDKTA NNHVIKMQRQ FSQLPNNGAA
     AGSMNPETMR DAHSEDMGQE QEFSYVDPIR RAILEKYVVH AFLERELMKV RGIEYVLANV
     REPDFWVIKK QRRTSPTAIE PLQTYYIVGA NVYQSPTVFK IVQSRLLACS SHLSATLAEL
     NNLVEFKPSQ GVQYKNILDM PVTTRKTGNT ANVGSVPGTI SASLNMPMVN TGRLNSAGAA
     TIGTSGVPNS AGMTGANTMA TGQTGATSRF ENGSSRSSTD AISTDTLDKL LITSMKSTPE
     YI