ID   MED6_COCIM              Reviewed;         353 AA.
AC   Q1E3Z7; A0A0D6K9Q8; J3KMD4;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 2.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 6;
DE   AltName: Full=Mediator complex subunit 6;
GN   Name=MED6; ORFNames=CIMG_02716;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 6 family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; GG704911; EAS37362.2; -; Genomic_DNA.
DR   RefSeq; XP_001248945.2; XM_001248944.2.
DR   AlphaFoldDB; Q1E3Z7; -.
DR   STRING; 246410.Q1E3Z7; -.
DR   EnsemblFungi; EAS37362; EAS37362; CIMG_02716.
DR   GeneID; 4567688; -.
DR   KEGG; cim:CIMG_02716; -.
DR   VEuPathDB; FungiDB:CIMG_02716; -.
DR   InParanoid; Q1E3Z7; -.
DR   OMA; FIVGEEP; -.
DR   OrthoDB; 1251252at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   Gene3D; 3.10.450.580; -; 1.
DR   InterPro; IPR007018; Mediator_Med6.
DR   InterPro; IPR038566; Mediator_Med6_sf.
DR   PANTHER; PTHR13104; PTHR13104; 1.
DR   Pfam; PF04934; Med6; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..353
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   6"
FT                   /id="PRO_0000303055"
FT   REGION          193..231
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          296..353
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        197..231
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   353 AA;  37790 MW;  CA0A2EF32AB5AA87 CRC64;
     MEPSPDVPLE EITWHSPQHV QMMGGFLHSN NILFYFAESP FFDPTSNNAS LALQAMHNEN
     LRPFIETRGA FEGRLKTMQG LEFIVAHDPL LEAAAANAAA VARGEQPKEA SNVWVIRKQM
     RRRSAAMGGQ DDVQVLATYF VVGDSVFMAP SVWSVVGRRM LSTVTSLTKV LSTASALLTF
     SPSYGHSYLP HVPKSLEPTQ LGQQSAQQSK ETTPMPDMSG DKTTSRSALA DASTTTLNAS
     ALQDARDFAE TLNLLARYGN EYIDETPLAG EPGSFIFTKA SASAAEQLSV AGAGAQASRQ
     NIRSGATTPV PFGAGRPASV QPDSTKGKAA DRPPAATKDK GKKRKSKIGS MSQ