ID   MED6_CRYNJ              Reviewed;         357 AA.
AC   P0CO74; Q560B9; Q5KPC2;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 6;
DE   AltName: Full=Mediator complex subunit 6;
GN   Name=MED6; OrderedLocusNames=CNA03340;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 6 family.
CC       {ECO:0000305}.
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DR   EMBL; AE017341; AAW40843.1; -; Genomic_DNA.
DR   RefSeq; XP_566662.1; XM_566662.1.
DR   AlphaFoldDB; P0CO74; -.
DR   SMR; P0CO74; -.
DR   STRING; 5207.AAW40843; -.
DR   PaxDb; P0CO74; -.
DR   EnsemblFungi; AAW40843; AAW40843; CNA03340.
DR   GeneID; 3254009; -.
DR   KEGG; cne:CNA03340; -.
DR   VEuPathDB; FungiDB:CNA03340; -.
DR   eggNOG; KOG3169; Eukaryota.
DR   HOGENOM; CLU_897192_0_0_1; -.
DR   InParanoid; P0CO74; -.
DR   OMA; NAFDYFT; -.
DR   OrthoDB; 1251252at2759; -.
DR   Proteomes; UP000002149; Chromosome 1.
DR   GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 3.10.450.580; -; 1.
DR   InterPro; IPR007018; Mediator_Med6.
DR   InterPro; IPR038566; Mediator_Med6_sf.
DR   PANTHER; PTHR13104; PTHR13104; 1.
DR   Pfam; PF04934; Med6; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..357
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   6"
FT                   /id="PRO_0000303056"
FT   REGION          151..219
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          323..357
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        151..187
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   357 AA;  38313 MW;  3BC3DED09F80649E CRC64;
     MAQQVEEIEQ DLSHIHWSWP EAIAANPARS LATPDLAMDY FAYSPFWDAK SNNNVLRTQR
     RIENPAYGHA EEKVELNAFM SGFEYVVAHS QPPDLFVIHR REVESSGKRD RVTGAWFILH
     EKIYQCPTLF DVMSTRLKNA TSLISKTLST LSENRPPANP RTTTLWRSIP SVTSNQPDGT
     QPSSLDQAEK PDEGKKDDSL NGSSPLDGSD GKASPAGPDW HLFHALQATR ASLVSLETLA
     KTPTQTTDPR EELNNIEIAM DNQFGGQNQS LSGKGPNVKG GAAAVKNISV PFVPKHSAGH
     ATSTTGLTPS IWGGSASLGV STAAVPAREA GGSPLKWPGG DKSAPIAGAT LAGQTGR