ID   MED6_DANRE              Reviewed;         254 AA.
AC   Q6IQ63;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 6;
DE   AltName: Full=Mediator complex subunit 6;
GN   Name=med6; ORFNames=zgc:86933;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 6 family.
CC       {ECO:0000305}.
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DR   EMBL; BC071547; AAH71547.1; -; mRNA.
DR   RefSeq; NP_001002084.1; NM_001002084.1.
DR   AlphaFoldDB; Q6IQ63; -.
DR   SMR; Q6IQ63; -.
DR   STRING; 7955.ENSDARP00000044114; -.
DR   PaxDb; Q6IQ63; -.
DR   Ensembl; ENSDART00000044115; ENSDARP00000044114; ENSDARG00000034734.
DR   GeneID; 415174; -.
DR   KEGG; dre:415174; -.
DR   CTD; 10001; -.
DR   ZFIN; ZDB-GENE-040625-61; med6.
DR   eggNOG; KOG3169; Eukaryota.
DR   GeneTree; ENSGT00390000017666; -.
DR   HOGENOM; CLU_077754_1_0_1; -.
DR   InParanoid; Q6IQ63; -.
DR   OMA; HLHNMIG; -.
DR   OrthoDB; 1251252at2759; -.
DR   PhylomeDB; Q6IQ63; -.
DR   TreeFam; TF313577; -.
DR   Reactome; R-DRE-212436; Generic Transcription Pathway.
DR   PRO; PR:Q6IQ63; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 13.
DR   Bgee; ENSDARG00000034734; Expressed in gastrula and 29 other tissues.
DR   ExpressionAtlas; Q6IQ63; baseline.
DR   GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 3.10.450.580; -; 1.
DR   InterPro; IPR007018; Mediator_Med6.
DR   InterPro; IPR016820; Mediator_Med6_met/pln.
DR   InterPro; IPR038566; Mediator_Med6_sf.
DR   PANTHER; PTHR13104; PTHR13104; 1.
DR   Pfam; PF04934; Med6; 1.
DR   PIRSF; PIRSF023869; Mediator_MED6_meta/pln; 1.
PE   2: Evidence at transcript level;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..254
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   6"
FT                   /id="PRO_0000303043"
FT   REGION          190..254
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        201..225
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        226..245
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   254 AA;  29250 MW;  CC17252A319A9A5D CRC64;
     MATVDLRDNL LGISWVDSGW VPILNPSNVL EYFSERSNPF YDRTCNNEVV KMQRSTLDHL
     TQLVGVEYIL LHTQEPILYI IRKQQRQSPT QVIPLADYYI IAGVVYQAPD LGSVISSRAL
     SAVHGIQSAF DEAMSFCRYH PSKGYWWHFK DQEEKERVKP KSKRKEEPSS LFQRQRVDTL
     LLDLRNKFPP TFYQTKPGEK PVPVEVKKEP EVPVETVKPQ EERETKPPAP PAPPRPPPQT
     TPNKPPPEKR ARVQ