ID   MED6_PICST              Reviewed;         263 AA.
AC   A3LQ10;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 2.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 6;
DE   AltName: Full=Mediator complex subunit 6;
GN   Name=MED6; ORFNames=PICST_55363;
OS   Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS   Y-11545) (Yeast) (Pichia stipitis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX   NCBI_TaxID=322104;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX   PubMed=17334359; DOI=10.1038/nbt1290;
RA   Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA   Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA   Passoth V., Richardson P.M.;
RT   "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT   yeast Pichia stipitis.";
RL   Nat. Biotechnol. 25:319-326(2007).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 6 family.
CC       {ECO:0000305}.
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DR   EMBL; CP000496; ABN64595.2; -; Genomic_DNA.
DR   RefSeq; XP_001382624.2; XM_001382587.1.
DR   AlphaFoldDB; A3LQ10; -.
DR   SMR; A3LQ10; -.
DR   STRING; 4924.XP_001382624.2; -.
DR   EnsemblFungi; ABN64595; ABN64595; PICST_55363.
DR   GeneID; 4837647; -.
DR   KEGG; pic:PICST_55363; -.
DR   eggNOG; KOG3169; Eukaryota.
DR   HOGENOM; CLU_077754_0_1_1; -.
DR   InParanoid; A3LQ10; -.
DR   OMA; MQRQFSQ; -.
DR   OrthoDB; 1251252at2759; -.
DR   Proteomes; UP000002258; Chromosome 2.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   Gene3D; 3.10.450.580; -; 1.
DR   InterPro; IPR007018; Mediator_Med6.
DR   InterPro; IPR016612; Mediator_Med6_fun.
DR   InterPro; IPR038566; Mediator_Med6_sf.
DR   PANTHER; PTHR13104; PTHR13104; 1.
DR   Pfam; PF04934; Med6; 1.
DR   PIRSF; PIRSF013286; MED6_fungi; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..263
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   6"
FT                   /id="PRO_0000303062"
FT   REGION          163..232
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   263 AA;  29149 MW;  D6C14FB6B54A4E73 CRC64;
     MSGEALDEIQ WKSPEFIQER GLHTGNVLEY FSLSPFYDRT SNNQQLMMQF QFQQIQIPVN
     TTFQQFFQEK LREMTGVVFV IAYNREPDFW IIRKQLQLDP QNAVTLQDYY IIGANVYQAP
     KVYDVLSSRL LSSVLQLRNS IDLLNKMTQF HVSDGGHSYN NAIHQSTSNP TQGQSSGKSI
     SATVGNTGTT ATPMTMQTPQ TVGPNGPATV QSGANSAAAI SKNGSTSSAE SADDRKNIYL
     DDIPLYGRGS TVEMLGLKVN LES